Protein Labeling & Modification

Fluorescent chemical dyes are relatively small, can have good photophysical properties and span the color spectrum, making them attractive alternatives to fluorescent proteins for labeling proteins. Researchers are actively developing tools for labeling proteins with dyes in living cells. Protein modifications play a decisive role in regulating cellular microenvironment by turning on/off the downstream signaling network and influence the pathophysiological sequel of diseases. Changes in tertiary structure of proteins brought about by specific chemical conjugation affect key cellular processes, viz. cellular differentiation, protein-protein interaction, protein degradation, as well as the regulatory functions of the affected proteins.