Innate immunity is the body’s first line of defense against pathogens and other harmful substances. It is essentially made up of barriers that aim to keep viruses, bacteria, parasites, and other foreign particles out of your body or limit their ability to spread and move throughout the body. The innate immune system includes physical barriers such as skin, the gastrointestinal tract, the respiratory tract, and the urinary tract. It also includes chemical barriers such as enzymes in tears and skin oils that kill bacteria. The innate immune system relies on the recognition of particular types of molecules that are common to many pathogens but are absent in the host. These pathogen-associated molecules stimulate two types of innate immune responses—inflammatory responses and phagocytosis by cells such as neutrophils and macrophages.
Innate Immunity
- Goat Anti-Rabbit IgG H&L (APC)Species reactivity(Reacts with): RabbitHost species: Goat Conjugation: APCSynonyms:Goat Anti-Rabbit IgG H&L Antibody (APC) | Anti-Rabbit IgG H&L Antibody (APC) | Rabbit IgG H&L Antibody (APC) | APC -c...
- TMP780Cas#:1422053-03-9(DMSO)Formula: C31H30N2O4 Molecular Weight:494.58SMILES:O=C(N[C@H](C1=CC=C(C)C=C1C)C2=CC=CC=C2)CC3=CC=C(OC([C@@H](C4=C(C)ON=C4C)O)=C5)C5=C3
- PF-06747711Cas#:1892576-58-7(DMSO)Formula: C26H26F3N5O2 Molecular Weight:497.51SMILES:CC(C)C(=O)N1CCC(CC1)C2=CN(C3=NC=C(C(=C23)C(F)(F)F)NC(=O)C4=CC=CC(=C4)C#N)C
- Gardiquimod diTFACas#:1159840-61-5(DMSO)Formula: C21H25F6N5O5 Molecular Weight:541.4SMILES:CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
- GSK805Cas#:1426802-50-7(DMSO)Formula: C23H18Cl2F3NO4S Molecular Weight:532.4SMILES:CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl
- Resiquimod-d5Cas#:2252319-44-9(DMSO)Formula: C17H17D5N4O2 Molecular Weight:319.41SMILES:CC(C)(O)CN1C2=C(N=C1COC([2H])([2H])C([2H])([2H])[2H])C(N)=NC3=CC=CC=C23
- RORγt Inverse agonist 6Cas#:1887161-80-9(DMSO)Formula: C28H29ClN6O5 Molecular Weight:565.02SMILES:O=C([C@H]1CN(C(NC2=CC3=C(N(C(C)C)C(N(CC4CC4)C3=O)=O)C=C2)=O)CCO1)NC5=CC=C(C#N)C(Cl)=C5
- TMP920Cas#:1421837-45-7(DMSO)Formula: C29H30N2O3 Molecular Weight:454.56SMILES:O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C
- S18-000003Cas#:2068119-11-7(DMSO)Formula: C26H25F3N2O4S Molecular Weight:518.55SMILES:CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C=C2)C(C)(C)C(=O)NC3=C(C=C(C=C3)F)F)F
- K6PC-5Cas#:756875-51-1(DMSO)Formula: C19H37NO4 Molecular Weight:343.5SMILES:CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
- RORγt Inverse agonist 6Cas#:1887161-80-9Formula: C28H29ClN6O5 Molecular Weight:565.02SMILES:O=C([C@H]1CN(C(NC2=CC3=C(N(C(C)C)C(N(CC4CC4)C3=O)=O)C=C2)=O)CCO1)NC5=CC=C(C#N)C(Cl)=C5
- TMP780Cas#:1422053-03-9Formula: C31H30N2O4 Molecular Weight:494.58SMILES:O=C(N[C@H](C1=CC=C(C)C=C1C)C2=CC=CC=C2)CC3=CC=C(OC([C@@H](C4=C(C)ON=C4C)O)=C5)C5=C3
- Gardiquimod diTFACas#:1159840-61-5 Compound CID : 44592365Formula: C21H25F6N5O5 Molecular Weight:541.4IUPAC Name:1-[4-amino-2-(ethylaminomethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol;2,2,2-trifluoroacetic acidSMILES:CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)OInChIKey:XFQPQSJDMJVOBN-UHFFFAOYSA-NInChI:XFQPQSJDMJVOBN-UHFFFAOYSA-NSynonyms:1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-alpha,alpha-dimethyl-, 2,2,2-trifluoroacetate (1...
- TMP920Cas#:1421837-45-7Formula: C29H30N2O3 Molecular Weight:454.56SMILES:O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C
- S18-000003Cas#:2068119-11-7 Compound CID : 137796283Formula: C26H25F3N2O4S Molecular Weight:518.55IUPAC Name:N-(2,4-difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamideSMILES:CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C=C2)C(C)(C)C(=O)NC3=C(C=C(C=C3)F)F)FInChIKey:DZUAIKQCQQBQJM-UHFFFAOYSA-NInChI:DZUAIKQCQQBQJM-UHFFFAOYSA-N
- K6PC-5Cas#:756875-51-1 Compound CID : 11660192Formula: C19H37NO4 Molecular Weight:343.5IUPAC Name:N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamideSMILES:CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)COInChIKey:CGYVFCHCRBGGJG-UHFFFAOYSA-NInChI:CGYVFCHCRBGGJG-UHFFFAOYSA-NSynonyms:9UO46U4GM1 | DTXSID50997113 | HY-124042 | N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide | UNII-9UO46U4GM1 | F8...
- Resiquimod-d5Cas#:2252319-44-9 Compound CID : 149852872Formula: C17H17D5N4O2 Molecular Weight:319.41SMILES:[2H]C([2H])([2H])C([2H])([2H])OCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
- RORγt agonist 3Cas#:2664106-24-3Formula: C34H37N3O3S Molecular Weight:567.74SMILES:N#CC[C@@H](C1=CC=C(C=C1)S(CC)(=O)=O)NC(C(C=C2)=CC=C2N(C3=CC(C4CC4)=CC(C5CC5)=C3)CC6CC6)=O
- XY101Cas#:2349368-16-5 Compound CID : 138105957Formula: C25H20F7NO4S Molecular Weight:563.48IUPAC Name:2-(4-ethylsulfonylphenyl)-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]acetamideSMILES:CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)FInChIKey:AUIAOCHKUNGZHV-UHFFFAOYSA-NInChI:AUIAOCHKUNGZHV-UHFFFAOYSA-N
- RORγt inverse agonist 23Cas#:2230779-18-5Formula: C26H33NO5S Molecular Weight:471.61SMILES:OC1C2=C(C=CC(S(N(C3=CC=C(CC)C=C3)C4CCC4)(=O)=O)=C2)OC(C5CCOCC5)C1
- Sparstolonin BCas#:1259330-61-4 Compound CID : 135659042Formula: C15H8O5 Molecular Weight:268.22IUPAC Name:4,14-dihydroxy-8,15-dioxatetracyclo[7.7.1.02,7.013,17]heptadeca-1(16),2(7),3,5,9(17),10,13-heptaen-12-oneSMILES:C1=CC2=C(C=C1O)C3=COC(=C4C3=C(O2)C=CC4=O)OInChIKey:KUPDHLFGNQEASI-UHFFFAOYSA-NInChI:KUPDHLFGNQEASI-UHFFFAOYSA-N
- CedirogantCas#:2055496-11-0 Compound CID : 124123797Formula: C24H20Cl3F3N2O3 Molecular Weight:547.78SMILES:C1CN(CCC1CC(=O)O)C(=O)C2=C(C(=C(C=C2)Cl)CN3C=CC4=CC(=CC(=C43)Cl)C(F)(F)F)Cl
- GNE-6468Cas#:1677668-27-7 Compound CID : 117964975Formula: C23H16ClN3O4 Molecular Weight:433.84IUPAC Name:4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acidSMILES:C1CC1C2=C(C(=CC=C2)Cl)C(=O)C3=NC(=C4N3C=CC=N4)C5=CC(=C(C=C5)C(=O)O)OInChIKey:GIYKJPISDNWSJD-UHFFFAOYSA-NInChI:GIYKJPISDNWSJD-UHFFFAOYSA-N
- PF-06747711Cas#:1892576-58-7 Compound CID : 118977746Formula: C26H26F3N5O2 Molecular Weight:497.51IUPAC Name:3-cyano-N-[1-methyl-3-[1-(2-methylpropanoyl)piperidin-4-yl]-4-(trifluoromethyl)pyrrolo[2,3-b]pyridin-5-yl]benzamideSMILES:CC(C)C(=O)N1CCC(CC1)C2=CN(C3=NC=C(C(=C23)C(F)(F)F)NC(=O)C4=CC=CC(=C4)C#N)CInChIKey:BIHPJIJLDNUDGH-UHFFFAOYSA-NInChI:BIHPJIJLDNUDGH-UHFFFAOYSA-N
- RORγt Inverse agonist 3Cas#:2364429-77-4Formula: C29H31Cl2N5O4S Molecular Weight:616.56SMILES:CC(C)C1=NC2=C(C=CC=C2OCC3=C(Cl)C=CC(S(=O)(N4CCC[C@H]4C(NC)=O)=O)=C3Cl)C(C5=CN=CN5C)=C1
- G140Cas#:2369751-07-3 Compound CID : 139388865Formula: C17H16Cl2N4O2 Molecular Weight:379.24IUPAC Name:1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanoneSMILES:CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)ClInChIKey:NVPFAXHXXODQRO-UHFFFAOYSA-NInChI:NVPFAXHXXODQRO-UHFFFAOYSA-N
- RORγt Inverse agonist 10Cas#:2413986-35-1Formula: C25H26F6N6O3 Molecular Weight:572.50SMILES:C[C@H](N(C(CC(C(F)(F)F)C(F)(F)F)=O)CC1)C[C@H]1OC2=C(C)C(NC(C3=CN=C(C)C=C3)=O)=CN4C2=NC=N4
- RO8191Cas#:691868-88-9 Compound CID : 2768133Formula: C14H5F6N5O Molecular Weight:373.21IUPAC Name:2-[2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl]-1,3,4-oxadiazoleSMILES:C1=CC2=NC(=CN2C3=C1C(=CC(=N3)C(F)(F)F)C(F)(F)F)C4=NN=CO4InChIKey:GRHYZVJEXKTJOS-UHFFFAOYSA-NInChI:GRHYZVJEXKTJOS-UHFFFAOYSA-NSynonyms:F77218 | NCGC00408901-01 | AKOS005079117 | CS-0055822 | MixCom2_000289 | 2-(2,4-bis(trifluoromethyl)imidazo[1,2-a][1,...
- JNJ-61803534Cas#:1917306-14-9Formula: C23H23Cl2F6N3O4S Molecular Weight:622.41SMILES:O=C(C1=NC(C(N2[C@H](C)CCC2)=O)=C(C3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C(Cl)=C3Cl)S1)NCC(C)(O)C
- XY101Cas#:2349368-16-5(DMSO)Formula: C25H20F7NO4S Molecular Weight:563.48SMILES:CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)F
- Sparstolonin BCas#:1259330-61-4(DMSO)Formula: C15H8O5 Molecular Weight:268.22SMILES:C1=CC2=C(C=C1O)C3=COC(=C4C3=C(O2)C=CC4=O)O
- RORγt inverse agonist 13Cas#:2170477-75-3(DMSO)Formula: C23H17Cl2F3N2O4 Molecular Weight:513.29SMILES:O=C(O)CC1=CC=C(CNC(NC2=CC(Cl)=C(C3=CC=CC=C3OC(F)(F)F)C(Cl)=C2)=O)C=C1
- TMP778Cas#:1422053-04-0(DMSO)Formula: C31H30N2O4 Molecular Weight:494.58SMILES:CC1=NOC(C)=C1[C@@H](C2=CC3=CC(CC(N[C@H](C4=CC=C(C)C=C4C)C5=CC=CC=C5)=O)=CC=C3O2)O
- BevurogantCas#:1817773-66-2(DMSO)Formula: C26H28N8O3S Molecular Weight:532.62SMILES:C[C@@H](C1CC1)N2C3=NC(C4=C(C)N=CN=C4C5CC5)=NC=C3N=C(C2=O)NCC6=CC=C(C=N6)S(C)(=O)=O
- CedirogantCas#:2055496-11-0(DMSO)Formula: C24H20Cl3F3N2O3 Molecular Weight:547.78SMILES:O=C(CC1CCN(CC1)C(C2=CC=C(C(CN3C=CC4=C3C(Cl)=CC(C(F)(F)F)=C4)=C2Cl)Cl)=O)O