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Cytokines are small proteins that are secreted by cells and have a specific effect on the interactions and communications between cells. In tumor immunology, cytokines are used to activate the immune system to suppress tumors. Th1-type cytokines including IL-1, IL-2, IL-12 and granulocyte-macrophage colony-stimulating factor are potent stimulators of Th1 differentiation and Th1-based antitumor response.