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CAY10502 - 98%, high purity , CAS No.888320-29-4, Inhibitor of cPLA 2-4A

Item Number

C337369

Grouped product items
SKU	Size	Availability	Price	Qty
C337369-1mg	1mg	In stock	$73.90
C337369-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$307.90

a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor

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Basic Description

Synonyms	CAY10502\|888320-29-4\|1-[3-(4-decoxyphenoxy)-2-oxopropyl]-3-methoxycarbonylindole-5-carboxylic acid\|CHEMBL443834\|compound 57 [PMID: 16610804]\|GTPL8771\|SCHEMBL22187718\|HMS3650G20\|BDBM50185354\|AKOS040755902\|MS-29698\|HY-116301\|CS-0064898\|SR-01000946287\|SR-010
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cPLA 2-4A
Product Description	CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with an IC50 value of 4.3 nM for the purified enzyme from human platelets. Inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	1-[3-(4-decoxyphenoxy)-2-oxopropyl]-3-methoxycarbonylindole-5-carboxylic acid
INCHI	InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
InChi Key	NXDZVUAKVFVDSL-UHFFFAOYSA-N
Canonical SMILES	CCCCCCCCCCOC1=CC=C(C=C1)OCC(=O)CN2C=C(C3=C2C=CC(=C3)C(=O)O)C(=O)OC
Isomeric SMILES	CCCCCCCCCCOC1=CC=C(C=C1)OCC(=O)CN2C=C(C3=C2C=CC(=C3)C(=O)O)C(=O)OC
Alternate CAS	888320-29-4
PubChem CID	11670893
Molecular Weight	523.62

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3 results found

Lot Number	Certificate Type	Date	Item
B2421028	Certificate of Analysis	Aug 16, 2022	C337369
K2216346	Certificate of Analysis	Aug 16, 2022	C337369
K2216348	Certificate of Analysis	Aug 16, 2022	C337369

1. Ludwig J, Bovens S, Brauch C, Elfringhoff AS, Lehr M. (2006) Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.. J Med Chem, 49 (8): (2611-20). [PMID:16610804]

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