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CAY10589 , CAS No.1077626-52-8
an inhibitor of 5-LO, Cox-1, and Cox-2
Basic Description Synonyms CAY10589|1077626-52-8|CHEMBL462523|2-[(4-{[([1,1'-Biphenyl]-4-yl)methyl]amino}-6-chloropyrimidin-2-yl)sulfanyl]octanoic acid|DTXSID10648876|CHEBI:186524|HMS3648E16|BDBM50273710|CAY 10589|CAY-10589|AKOS040745653|2-[4-chloro-6-[(4-phenylphenyl)methylamino]p Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description CAY10589 is an inhibitor of mPGES-1 (IC|50|= 1.3 μM), 5-LO (IC|50|= 1.0 μM), and PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 exhibits minor inhibition of Cox-1 and Cox-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.
Names and Identifiers IUPAC Name 2-[4-chloro-6-[(4-phenylphenyl)methylamino]pyrimidin-2-yl]sulfanyloctanoic acid INCHI InChI=1S/C25H28ClN3O2S/c1-2-3-4-8-11-21(24(30)31)32-25-28-22(26)16-23(29-25)27-17-18-12-14-20(15-13-18)19-9-6-5-7-10-19/h5-7,9-10,12-16,21H,2-4,8,11,17H2,1H3,(H,30,31)(H,27,28,29) InChi Key FQMPYBCEABTPIK-UHFFFAOYSA-N Canonical SMILES CCCCCCC(C(=O)O)SC1=NC(=CC(=N1)Cl)NCC2=CC=C(C=C2)C3=CC=CC=C3 Isomeric SMILES CCCCCCC(C(=O)O)SC1=NC(=CC(=N1)Cl)NCC2=CC=C(C=C2)C3=CC=CC=C3 PubChem CID 25147690 Molecular Weight 470
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