CC-401 - ≥98%, high purity , CAS No.395104-30-0, Inhibitor of maternal embryonic leucine zipper kinase

Item Number

C339031

Grouped product items
SKU	Size	Availability	Price	Qty
C339031-2mg	2mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$314.90
C339031-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,007.90

an ATP-competitive JNK inhibitor

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Basic Description

Synonyms	CC-401\|395104-30-0\|3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole\|NOE38VQA1W\|3-[3-(2-piperidin-1-ylethoxy)phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole\|3-[3-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-5-(1H-1,2,4-TRIAZOL-5-YL)-1H-INDAZO
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of maternal embryonic leucine zipper kinase
Product Description	CC-401 is a second generation ATP-competitive anthrapyrazolone JNK (c-Jun N terminal kinase) inhibitor with potential antineoplastic activity.

Names and Identifiers

IUPAC Name	3-[3-(2-piperidin-1-ylethoxy)phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
INCHI	InChI=1S/C22H24N6O/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27)
InChi Key	XDJCLCLBSGGNKS-UHFFFAOYSA-N
Canonical SMILES	C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5
Isomeric SMILES	C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5
Alternate CAS	395104-30-0
PubChem CID	10430360
MeSH Entry Terms	CC 401;CC-401;CC401 cpd
Molecular Weight	388.47

References

1. Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, Yeh B, Moeller HP, Nichols RJ, McCutcheon D et al.. (2018) CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition.. Endocrinology, 159 (9): (3143-3157). [PMID:29514186]
2. Han SY. (2008) c-Jun N-Terminal Kinase Signaling Inhibitors Under Development.. Toxicol Res, 24 (2): (93-100). [PMID:32038782]

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Basic Description