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CC-930 - 98%, high purity , CAS No.899805-25-5, Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Moligand™
≥98%

CAS#: 899805-25-5
Formula: C₂₁H₂₃F₃N₆O₂
Molecular Weight: 448.44
PubChem CID: 11597537

Item Number

C126262

Grouped product items
SKU	Size	Availability	Price
C126262-5mg	5mg	In stock	$107.90
C126262-10mg	10mg	In stock	$179.90
C126262-25mg	25mg	In stock	$405.90
C126262-50mg	50mg	In stock	$717.90
C126262-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$954.90

View related series

mitogen-activated protein kinase 10 Inhibitor mitogen-activated protein kinase 8 Inhibitor mitogen-activated protein kinase 9 Inhibitor

Basic Description

Synonyms	TANZISERTIB\|899805-25-5\|CC-930\|Tanzisertib [USAN]\|CC-930(Tanzisertib)\|CC 930\|CHEMBL1950289\|JNK-930; JNKI-1\|JNK-930\|CC930\|M5O06306UO\|Tanzisertib (USAN)\|(1S,4r)-4-((9-((S)-tetrahydrofuran-3-yl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)cyclohexan
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 10;Inhibitor of mitogen-activated protein kinase 8;Inhibitor of mitogen-activated protein kinase 9

Associated Targets

MAPK10 Tchem Mitogen-activated protein kinase 10 4 Activities

Discover Target: MAPK10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK8 Tchem Mitogen-activated protein kinase 8 2 Activities

Discover Target: MAPK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK9 Tchem Mitogen-activated protein kinase 9 6 Activities

Discover Target: MAPK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[[9-[(3S)-oxolan-3-yl]-8-(2,4,6-trifluoroanilino)purin-2-yl]amino]cyclohexan-1-ol
INCHI	InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12?,13-,14?/m0/s1
InChi Key	IBGLGMOPHJQDJB-MOKVOYLWSA-N
Canonical SMILES	C1CC(CCC1NC2=NC=C3C(=N2)N(C(=N3)NC4=C(C=C(C=C4F)F)F)C5CCOC5)O
Isomeric SMILES	C1COC[C@H]1N2C3=NC(=NC=C3N=C2NC4=C(C=C(C=C4F)F)F)NC5CCC(CC5)O
PubChem CID	11597537
Molecular Weight	448.44

ChEMBL Ligand

CHEMBL1950289

PubChem CID

11597537

CAS Registry No.

899805-25-5

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
A2208179	Certificate of Analysis	Oct 09, 2023	C126262
A2208181	Certificate of Analysis	Oct 09, 2023	C126262
A2208182	Certificate of Analysis	Oct 09, 2023	C126262
A2208183	Certificate of Analysis	Oct 09, 2023	C126262

References

1. Plantevin Krenitsky V, Nadolny L, Delgado M, Ayala L, Clareen SS, Hilgraf R, Albers R, Hegde S, D'Sidocky N, Sapienza J et al.. (2012) Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.. Bioorg Med Chem Lett, 22 (3): (1433-8). [PMID:22244937]
2. van der Velden JL, Ye Y, Nolin JD, Hoffman SM, Chapman DG, Lahue KG, Abdalla S, Chen P, Liu Y, Bennett B et al.. (2016) JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.. Clin Transl Med, 5 (1): (36). [PMID:27590145]

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