JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

CC-99677 , CAS No.C608352, Inhibitor of MAPK activated protein kinase 2

Item Number

C608352

Grouped product items
SKU	Size	Availability	Price	Qty
C608352-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$670.90
C608352-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,200.90

View related series

Basic Description

Synonyms	CC-99677\|1887069-10-4\|(R)-3-((2-Chloro-5-(ethoxymethyl)pyrimidin-4-yl)oxy)-10-methyl-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one\|Gamcemetinib\|OS2IR8TV1O\|GAMCEMETINIB [USAN]\|SCHEMBL17581285\|GTPL12167\|BDBM348829\|GLXC-26196\|
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MAPK activated protein kinase 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INCHI	InChI=1S/C22H20ClN5O3S/c1-3-30-10-12-9-25-22(23)28-21(12)31-16-7-4-13-14(27-16)5-6-15-17(13)18-19(32-15)20(29)26-11(2)8-24-18/h4-7,9,11,24H,3,8,10H2,1-2H3,(H,26,29)/t11-/m1/s1
InChi Key	PYOQIOLRFIRRSO-LLVKDONJSA-N
Canonical SMILES	CCOCc1cnc(nc1Oc1nc2c(cc1)c1c(cc2)sc2c1NC[C@H](NC2=O)C)Cl
Isomeric SMILES	CCOCC1=CN=C(N=C1OC2=NC3=C(C=C2)C4=C(C=C3)SC5=C4NC[C@H](NC5=O)C)Cl
PubChem CID	118936948

PubChem CID	118936948

Enter Lot Number to search for COA:

1. Malona J, Chuaqui C, Seletsky BM, Beebe L, Cantin S, VAN Kalken D, Fahnoe K, Wang Z, Browning B, Szabo H et al.. (2022) Discovery of CC-99677, a selective targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune disorders.. Transl Res, 129 (3): (589-97). [PMID:35691544]

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.