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CCG 203971 - ≥98%(HPLC), high purity , CAS No.1443437-74-8

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CCG 203971 - ≥98%(HPLC), high purity , CAS No.1443437-74-8

Moligand™
≥98%(HPLC)

CAS#: 1443437-74-8
Formula: C₂₃H₂₁ClN₂O₃
Molecular Weight: 408.88
PubChem CID: 71681561

Item Number

C287005

Grouped product items
SKU	Size	Availability	Price
C287005-5mg	5mg	In stock	$39.90
C287005-10mg	10mg	In stock	$64.90
C287005-25mg	25mg	In stock	$129.90
C287005-50mg	50mg	In stock	$205.90
C287005-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$314.90

Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent.

Basic Description

Synonyms	N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide；CCG-203971；N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide； CCG 203971, CCG-203971, CCG-203971 CCG 203971；CCG203971;N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperid
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF,α-SMA, and COL1A2 in SSc fibr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets

RHOA Tbio Transforming protein RhoA 0 Activities

Discover Target: RHOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(4-chlorophenyl)-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide
INCHI	InChI=1S/C23H21ClN2O3/c24-19-8-10-20(11-9-19)25-22(27)18-6-2-12-26(15-18)23(28)17-5-1-4-16(14-17)21-7-3-13-29-21/h1,3-5,7-11,13-14,18H,2,6,12,15H2,(H,25,27)
InChi Key	HERLZBNILRVHQN-UHFFFAOYSA-N
Canonical SMILES	C1CC(CN(C1)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl
Isomeric SMILES	C1CC(CN(C1)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl
PubChem CID	71681561
MeSH Entry Terms	CCG-203971;N-(4-chlorophenyl)-1-((3-(furan-2-yl)phenyl)carbonyl)piperidine-3-carboxamide
Molecular Weight	408.88

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5 results found

Lot Number	Certificate Type	Date	Item
C2209410	Certificate of Analysis	Feb 09, 2022	C287005
C2209411	Certificate of Analysis	Feb 09, 2022	C287005
C2209414	Certificate of Analysis	Feb 09, 2022	C287005
C2209415	Certificate of Analysis	Feb 09, 2022	C287005
C2209416	Certificate of Analysis	Feb 09, 2022	C287005

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 20.44, Max Conc. mM: 50

References

1. Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD. (2013) Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.. Bioorg Med Chem Lett, 23 (13): (3826-32). [PMID:23707258]

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