| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C413579-5mg | 5mg | In stock | $118.90 | |
| C413579-25mg | 25mg | In stock | $380.90 | |
| C413579-100mg | 100mg | In stock | $1,033.90 |
Rho Inhibitors
| Specifications & Purity | 98% |
|---|---|
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression. Targets Rho ; α-SMA In vitro CCG-222740 increases the protein levels of p27 and decreased cyclin D1. CCG-222740 treatment decreased cell viability of CAFs, with an IC50 of~10 μM, as measured by the MTT assay. In pancreatic cancer, CAFs are one of the main producers of matrix proteins, including several collagen isoforms. The Rho/MRTF pathway inhibitor CCG-222740 decreases the levels of collagens I, 2a and IV, as well as α-SMA in the CAFsIn cancer cells. CCG-222740 treatment leads to the exclusion of MRTF from the nucleus. . In vivo CCG-222740 significantly reduces α-SMA levels in the pancreas of caerulein- stimulated KC mice. Cell Research(from reference) Cell lines：Cancer associated fibroblasts (CAFs) Concentrations：10 μM and 20 μM Incubation Time：72 hours |
| ALogP | 3.99 |
|---|---|
| HBD Count | 1 |
| Rotatable Bond | 4 |
| IUPAC Name | N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide |
|---|---|
| INCHI | InChI=1S/C23H19ClF2N2O3/c24-18-6-8-19(9-7-18)27-21(29)17-12-23(25,26)14-28(13-17)22(30)16-4-1-3-15(11-16)20-5-2-10-31-20/h1-11,17H,12-14H2,(H,27,29) |
| InChi Key | PMTPYUTZAJWGPE-UHFFFAOYSA-N |
| Canonical SMILES | C1C(CN(CC1(F)F)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl |
| Isomeric SMILES | C1C(CN(CC1(F)F)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl |
| PubChem CID | 121317937 |
| Molecular Weight | 444.86 |
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2215142 | Certificate of Analysis | Jun 02, 2022 | C413579 |
| G2215143 | Certificate of Analysis | Jun 02, 2022 | C413579 |
| G2215185 | Certificate of Analysis | Jun 02, 2022 | C413579 |
| Solubility | Solubility (25°C) In vitro DMSO: 89 mg/mL (200.06 mM); Ethanol: 89 mg/mL (200.06 mM); Water: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 89 |
| DMSO(mM) Max Solubility | 200.062941150025 |
| Water(mg / mL) Max Solubility | ＜1 |
