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CCR2-RA-[R] , CAS No.C608420, Allosteric modulator of CCR2

  • Moligand™
Item Number
C608420
Grouped product items
SKUSizeAvailabilityPrice Qty
C608420-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
C608420-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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CCR2 Allosteric modulator

Basic Description

Synonymsanalog 49 (Dasse et al., 2007)
Specifications & PurityMoligand™
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of CCR2

Associated Targets

CCR2 Tchem C-C chemokine receptor type 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CCR5 Tclin C-C chemokine receptor type 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2R)-3-acetyl-1-(4-chloro-2-fluorophenyl)-2-cyclohexyl-4-hydroxy-2H-pyrrol-5-one
INCHI InChI=1S/C18H19ClFNO3/c1-10(22)15-16(11-5-3-2-4-6-11)21(18(24)17(15)23)14-8-7-12(19)9-13(14)20/h7-9,11,16,23H,2-6H2,1H3/t16-/m1/s1
InChi Key VQNLJXWZGVRLBA-MRXNPFEDSA-N
Canonical SMILES Clc1ccc(c(c1)F)N1[C@H](C2CCCCC2)C(=C(C1=O)O)C(=O)C
Isomeric SMILES CC(=O)C1=C(C(=O)N([C@@H]1C2CCCCC2)C3=C(C=C(C=C3)Cl)F)O
PubChem CID 12093170

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P et al..  (2016)  Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists..  Nature,  540  (7633): (458-461).  [PMID:27926736]
2. O'Connor T, Borsig L, Heikenwalder M.  (2015)  CCL2-CCR2 Signaling in Disease Pathogenesis..  Endocr Metab Immune Disord Drug Targets,  15  (2): (105-18).  [PMID:25772168]

Solution Calculators

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