1. Tsantili-Kakoulidou A, Nicolaou I, Vrakas D, Demopoulos VJ. (2005) Modelling of aldose reductase inhibitory activity of pyrrol-1-yl-acetic acid derivatives by means of multivariate statistics.. Med Chem, 1 (4): (321-6). [PMID:16789889] |
2. Figueroa F, Davicino R, Micalizzi B, Oliveros L, Forneris M. (2012) Macrophage secretions modulate the steroidogenesis of polycystic ovary in rats: effect of testosterone on macrophage pro-inflammatory cytokines.. Life Sci, 90 (19-20): (733-9). [PMID:22480516] |
3. Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A et al.. (2012) Novel β-amino acid derivatives as inhibitors of cathepsin A.. J Med Chem, 55 (17): (7636-49). [PMID:22861813] |
4. Deaton DN, Gao EN, Graham KP, Gross JW, Miller AB, Strelow JM. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.. Bioorg Med Chem Lett, 18 (2): (732-7). [PMID:18078750] |
5. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.. Bioorg Med Chem, 16 (19): (8781-94). [PMID:18790648] |
6. Bonnard E, Poras H, Nadal X, Maldonado R, Fournié-Zaluski MC, Roques BP. (2015) Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.. Pharmacol Res Perspect, 3 (2): (e00116). [PMID:25692029] |
7. Chen H, Noble F, Roques BP, Fournié-Zaluski MC. (2001) Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.. J Med Chem, 44 (21): (3523-30). [PMID:11585456] |
8. Pinto M, Rougeot C, Gracia L, Rosa M, García A, Arsequell G, Valencia G, Centeno NB. (2012) Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.. ACS Med Chem Lett, 3 (1): (20-4). [PMID:24900367] |
9. David C Pryde, Graham N Maw, Simon Planken, Michelle Y Platts, Vivienne Sanderson, Martin Corless, Alan Stobie, Christopher G Barber, Rachel Russell, Laura Foster, Laura Barker, Christopher Wayman, Piet Van Der Graaf, Peter Stacey, Debbie Morren, Christopher Kohl, Kevin Beaumont, Sara Coggon, Michael Tute,. (2006-07-11) Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.. Journal of medicinal chemistry, 49 ((14)): ( 4409-4424 ). [PMID:16821800] |
10. Fournié-Zaluski MC, Coric P, Turcaud S, Rousselet N, Gonzalez W, Barbe B, Pham I, Jullian N, Michel JB, Roques BP.. (1994) New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.. J Med Chem, 37 (8): (1070-1083). [PMID:8164250] |
11. Berger Y, Dehmlow H, Blum-Kaelin D, Kitas EA, Löffler BM, Aebi JD, Juillerat-Jeanneret L.. (2005) Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.. J Med Chem, 48 (2): (483-498). [PMID:15658862] |
12. Deaton DN, Graham KP, Gross JW, Miller AB.. (2008) Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.. Bioorg Med Chem Lett, 18 (5): (1681-1687). [PMID:18243695] |
13. Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A, Choudhry S, Fauq AH, Maharvi GM, Leissring MA.. (2013) Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.. J Med Chem, 56 (6): (2246-2255). [PMID:23437776] |
14. Charton J, Gauriot M, Guo Q, Hennuyer N, Marechal X, Dumont J, Hamdane M, Pottiez V, Landry V, Sperandio O, Flipo M, Buee L, Staels B, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R.. (2014) Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.. Eur J Med Chem, 79 (184-193). [PMID:24735644] |
15. Choi JY, Fuerst R, Knapinska AM, Taylor AB, Smith L, Cao X, Hart PJ, Fields GB, Roush WR.. (2017) Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.. J Med Chem, 60 (13): (5816-5825). [PMID:28653849] |
16. Sattigeri JA, Sethi S, Davis JA, Ahmed S, Rayasam GV, Jadhav BG, Chilla SM, Datta D, Gadhave A, Tulasi VK, Jain T, Voleti S, Benjamin B, Udupa S, Jain G, Singh Y, Srinivas K, Bansal VS, Ray A, Bhatnagar PK, Cliffe IA.. (2017) Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.. Bioorg Med Chem Lett, 27 (11): (2313-2318). [PMID:28442252] |
17. McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.. (2017) Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.. J Med Chem, 60 (14): (6408-6427). [PMID:28685579] |
18. McKinnell RM, Fatheree P, Choi SK, Gendron R, Jendza K, Olson Blair B, Budman J, Hill CM, Hegde LG, Yu C, McConn D, Hegde SS, Marquess DG, Klein U.. (2019) Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).. ACS Med Chem Lett, 10 (1): (86-91). [PMID:30655952] |
19. Kawanami T, Karki RG, Cody E, Liu Q, Liang G, Ksander GM, Rigel DF, Schiering N, Gong Y, Coppola GM, Iwaki Y, Sun R, Neubert A, Fan L, Ingles S, D'Arcy A, Villard F, Ramage P, Jeng AY, Leung-Chu J, Liu J, Beil M, Fu F, Chen W, Cumin F, Wiesmann C, Mogi M.. (2020) Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.. ACS Med Chem Lett, 11 (2): (188-194). [PMID:32071687] |
20. Sharma U, Cozier GE, Sturrock ED, Acharya KR.. (2020) Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.. J Med Chem, 63 (10): (5488-5500). [PMID:32337993] |
21. O'Connell, J E JE, Jardine, A G AG, Davidson, G G and Connell, J M JM.. (1992) Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension.. Journal of hypertension, [PMID:1315825] |
22. Elsner, D D, Müntze, A A, Kromer, E P EP and Riegger, G A GA.. (1992) Effectiveness of endopeptidase inhibition (candoxatril) in congestive heart failure.. The American journal of cardiology, (15): [PMID:1386491] |
23. D'Adamio, L L, Shipp, M A MA, Masteller, E L EL and Reinherz, E L EL.. (1989) Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2528730] |
24. Yandle, T G TG, Brennan, S O SO, Espiner, E A EA, Nicholls, M G MG and Richards, A M AM.. () Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126).. Peptides, [PMID:2531377] |
25. Shipp, M A MA and 7 more authors.. (1988) Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2968607] |
26. Letarte, M M and 7 more authors.. (1988) Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.. The Journal of experimental medicine, (1): [PMID:2971756] |
27. Vanneste, Y Y, Michel, A A, Dimaline, R R, Najdovski, T T and Deschodt-Lanckman, M M.. (1988) Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site.. The Biochemical journal, (1): [PMID:2972276] |
28. Malfroy, B B, Kuang, W J WJ, Seeburg, P H PH, Mason, A J AJ and Schofield, P R PR.. (1988) Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).. FEBS letters, (29): [PMID:3162217] |
29. Skidgel, R A RA, Engelbrecht, S S, Johnson, A R AR and Erdös, E G EG.. () Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase.. Peptides, [PMID:6208535] |
30. Hirata, Y Y and 6 more authors.. (1994) Mechanisms of the natriuretic effects of neutral endopeptidase inhibition in Dahl salt-sensitive and salt-resistant rats.. Journal of cardiovascular pharmacology, [PMID:7511759] |
31. Le Moual, H H, Dion, N N, Roques, B P BP, Crine, P P and Boileau, G G.. (1994) Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11.. European journal of biochemistry, (1): [PMID:8168535] |
32. Oefner, C C, D'Arcy, A A, Hennig, M M, Winkler, F K FK and Dale, G E GE.. (2000) Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.. Journal of molecular biology, (18): [PMID:10669592] |
33. Intengan, H D HD and Schiffrin, E L EL.. (2000) Vasopeptidase inhibition has potent effects on blood pressure and resistance arteries in stroke-prone spontaneously hypertensive rats.. Hypertension (Dallas, Tex. : 1979), [PMID:10856267] |
34. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352] |
35. Zhang, Hui H, Li, Xiao-Jun XJ, Martin, Daniel B DB and Aebersold, Ruedi R.. (2003) Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.. Nature biotechnology, [PMID:12754519] |
36. Oefner, Christian C, Roques, Bernard P BP, Fournie-Zaluski, Marie-Claude MC and Dale, Glenn E GE.. (2004) Structural analysis of neprilysin with various specific and potent inhibitors.. Acta crystallographica. Section D, Biological crystallography, [PMID:14747736] |
37. Rice, Gillian I GI, Thomas, Daniel A DA, Grant, Peter J PJ, Turner, Anthony J AJ and Hooper, Nigel M NM.. (2004) Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.. The Biochemical journal, (1): [PMID:15283675] |
38. Sansoè, Giovanni G and 9 more authors.. (2005) Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?. Journal of hepatology, [PMID:16085334] |
39. Sansoè, G G and 9 more authors.. (2006) Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis.. American journal of physiology. Renal physiology, [PMID:16449355] |
40. Wisner, Anne A and 6 more authors.. (2006) Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.. Proceedings of the National Academy of Sciences of the United States of America, (21): [PMID:17101991] |
41. Oefner, Christian C, Pierau, Sabine S, Schulz, Henk H and Dale, Glenn E GE.. (2007) Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.. Acta crystallographica. Section D, Biological crystallography, [PMID:17704566] |
42. Zheng, Rong R and 6 more authors.. (2010) Neutral endopeptidase is a myristoylated protein.. Molecular and cellular biochemistry, [PMID:19756956] |
43. Morisaki, Naoko N and 5 more authors.. (2010) Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses.. The Journal of biological chemistry, (17): [PMID:20876573] |
44. Bian, Yangyang Y and 9 more authors.. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.. Journal of proteomics, (16): [PMID:24275569] |
45. Smith, A Ian AI and 12 more authors.. (2016) N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.. Scientific reports, (2): [PMID:26931059] |
46. Higuchi, Yujiro Y and 32 more authors.. (2016) Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2.. Annals of neurology, [PMID:26991897] |
47. Depondt, Chantal C and 6 more authors.. (2016) MME mutation in dominant spinocerebellar ataxia with neuropathy (SCA43).. Neurology. Genetics, [PMID:27583304] |
48. Auer-Grumbach, Michaela M and 31 more authors.. (2016) Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies.. American journal of human genetics, (1): [PMID:27588448] |