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Size

Availability

Price

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Ab093787-10μg (Trial Size)
Apply for free trial size（?）

10μg

Available within 8-12 weeks(?)

$26.90

Ab093787-50μg

50μg

Available within 8-12 weeks(?)

$69.90

Ab093787-100μg

100μg

Available within 8-12 weeks(?)

$99.90

Ab093787-1mg

1mg

Available within 8-12 weeks(?)

$899.90

Basic Description

Product Name	CD13 Mouse mAb - Primary antibody, specific to CD13, Mouse IgG1
Synonyms	alanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD13 antigen; CD13; CD13APN; EC 3.4.11; EC 3.4.11.2; gp150; LAP1; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; p1
Specifications & Purity	ExactAb™, Validated, Carrier Free, Lot by Lot
Host species	Mouse
Specificity	CD13
Conjugate	Unconjugated
Grade	Carrier Free, ExactAb™, Validated

Product Properties

Isotype	Mouse IgG1
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Stability And Storage	Shipped at 4°C. Store at 4°C long term (36 months). Upon delivery aliquot.

Images

CD13 Mouse mAb (Ab093787) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling CD13 (red) with CD13 Mouse mAb (Ab093787) at 0.1 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (Alexa Fluor® 647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

CD13 Mouse mAb (Ab093787) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling CD13 (red) with CD13 Mouse mAb (Ab093787) at 0.1 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (Alexa Fluor® 647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

CD13 Mouse mAb (Ab093787) - Flow Cytometry
Flow Cytometry analysis of SK-N-SH cells labelling CD13 (red) with CD13 Mouse mAb (Ab093787) at 0.1 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (Alexa Fluor® 647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

CD13 Mouse mAb (Ab093787) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling CD13 (red) with CD13 Mouse mAb (Ab093787) at 0.1 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (Alexa Fluor® 647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

CD13 Mouse mAb (Ab093787) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling CD13 (red) with CD13 Mouse mAb (Ab093787) at 0.1 μg/mL for 1 hour at 4°C. AffiniPure Goat anti-Mouse IgG, Fcγ fragment specific (Alexa Fluor® 647) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Associated Targets

ANPEP Tchem Aminopeptidase N 0 Activities

Discover Target: ANPEP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Notes
Flow	< 0.5µg/100w cells

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0102455	Certificate of Analysis	Jan 18, 2024	Ab093787
ZJ24F0102454	Certificate of Analysis	Jan 18, 2024	Ab093787
ZJ24F0102453	Certificate of Analysis	Jan 18, 2024	Ab093787

References

1. Bonnard E, Poras H, Nadal X, Maldonado R, Fournié-Zaluski MC, Roques BP. (2015) Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.. Pharmacol Res Perspect, 3 (2): (e00116). [PMID:25692029]
2. Chen H, Noble F, Roques BP, Fournié-Zaluski MC. (2001) Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.. J Med Chem, 44 (21): (3523-30). [PMID:11585456]
3. Pascual I, Valiente PA, García G, Valdés-Tresanco ME, Arrebola Y, Díaz L, Bounaadja L, Uribe RM, Pacheco MC, Florent I et al.. (2017) Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).. Biochimie, 142 (3): (216-225). [PMID:28964831]
4. Yeager CL, Ashmun RA, Williams RK, Cardellichio CB, Shapiro LH, Look AT, Holmes KV. (1992) Human aminopeptidase N is a receptor for human coronavirus 229E.. Nature, 357 (6377): (420-2). [PMID:1350662]
5. Bonavia A, Zelus BD, Wentworth DE, Talbot PJ, Holmes KV. (2003) Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E.. J Virol, 77 (4): (2530-8). [PMID:12551991]
6. Pinto M, Rougeot C, Gracia L, Rosa M, García A, Arsequell G, Valencia G, Centeno NB. (2012) Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.. ACS Med Chem Lett, 3 (1): (20-4). [PMID:24900367]
7. Alan H M Wong,Dongxia Zhou,James M Rini. (2012-08-31) The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing.. The Journal of biological chemistry, 287 ((44)): (36804-36813). [PMID:22932899]
8. Kawai M, BaMaung NY, Fidanze SD, Erickson SA, Tedrow JS, Sanders WJ, Vasudevan A, Park C, Hutchins C, Comess KM, Kalvin D, Wang J, Zhang Q, Lou P, Tucker-Garcia L, Bouska J, Bell RL, Lesniewski R, Henkin J, Sheppard GS.. (2006) Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.. Bioorg Med Chem Lett, 16 (13): (3574-3577). [PMID:16632353]
9. Ahn JH, Shin MS, Jun MA, Jung SH, Kang SK, Kim KR, Rhee SD, Kang NS, Kim SY, Sohn SK, Kim SG, Jin MS, Lee JO, Cheon HG, Kim SS.. (2007) Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.. Bioorg Med Chem Lett, 17 (9): (2622-2628). [PMID:17331715]
10. Vassiliou S, Węglarz-Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Mulligan R, Joachimiak A, Mucha A.. (2014) Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.. J Med Chem, 57 (19): (8140-8151). [PMID:25192493]
11. Węglarz-Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Joachimiak A, Mucha A.. (2016) A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.. Eur J Med Chem, 117 (187-196). [PMID:27100031]
12. Węglarz-Tomczak E, Burda-Grabowska M, Giurg M, Mucha A.. (2016) Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.. Bioorg Med Chem Lett, 26 (21): (5254-5259). [PMID:27692546]
13. Sattigeri JA, Sethi S, Davis JA, Ahmed S, Rayasam GV, Jadhav BG, Chilla SM, Datta D, Gadhave A, Tulasi VK, Jain T, Voleti S, Benjamin B, Udupa S, Jain G, Singh Y, Srinivas K, Bansal VS, Ray A, Bhatnagar PK, Cliffe IA.. (2017) Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.. Bioorg Med Chem Lett, 27 (11): (2313-2318). [PMID:28442252]
14. Singh R, Williams J, Vince R.. (2017) Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies.. Eur J Med Chem, 139 (325-336). [PMID:28803047]
15. Jiang Y, Li X, Hou J, Huang Y, Wang X, Jia Y, Wang Q, Xu W, Zhang J, Zhang Y.. (2018) Synthesis and biological characterization of ubenimex-fluorouracil conjugates for anti-cancer therapy.. Eur J Med Chem, 143 (334-347). [PMID:29202398]
16. Yang YK, Shen DD, He P, Du LD, Wan DJ, Wang P, Wang T, Feng MQ.. (2019) Chemically synthesized LYRM03 could inhibit the metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo.. Bioorg Med Chem Lett, 29 (14): (1719-1726). [PMID:31126854]
17. Jiang Y,Hou J,Li X,Huang Y,Wang X,Wu J,Zhang J,Xu W,Zhang Y. (2016) Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity.. Bioorg Med Chem, 24 (22.0): (5787-5795). [PMID:27670098]
18. Shapiro, L H LH, Ashmun, R A RA, Roberts, W M WM and Look, A T AT.. (1991) Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.. The Journal of biological chemistry, (25): [PMID:1675638]
19. O'Connell, P J PJ, Gerkis, V V and d'Apice, A J AJ.. (1991) Variable O-glycosylation of CD13 (aminopeptidase N).. The Journal of biological chemistry, (5): [PMID:1705556]
20. Look, A T AT, Ashmun, R A RA, Shapiro, L H LH and Peiper, S C SC.. (1989) Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.. The Journal of clinical investigation, [PMID:2564851]
21. Olsen, J J and 9 more authors.. (1988) Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA.. FEBS letters, (10): [PMID:2901990]
22. Tokioka-Terao, M M, Hiwada, K K and Kokubu, T T.. (1984) Purification and characterization of aminopeptidase N from human plasma.. Enzyme, [PMID:6149934]
23. Watanabe, Y Y, Iwaki-Egawa, S S, Mizukoshi, H H and Fujimoto, Y Y.. (1995) Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N.. Biological chemistry Hoppe-Seyler, [PMID:7576235]
24. Favaloro, E J EJ, Browning, T T and Facey, D D.. (1993) CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated.. Experimental hematology, [PMID:7902291]
25. Núñez, L L and 6 more authors.. (1993) Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids.. FEBS letters, (23): [PMID:8102610]
26. Söderberg, C C and 5 more authors.. (1993) CD13 (human aminopeptidase N) mediates human cytomegalovirus infection.. Journal of virology, [PMID:8105105]
27. Kolb, A F AF, Maile, J J, Heister, A A and Siddell, S G SG.. (1996) Characterization of functional domains in the human coronavirus HCV 229E receptor.. The Journal of general virology, [PMID:8887485]
28. Norén, K K and 5 more authors.. (1997) Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity.. Experimental cell research, (25): [PMID:9056417]
29. Kolb, A F AF, Hegyi, A A and Siddell, S G SG.. (1997) Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N.. The Journal of general virology, [PMID:9367365]
30. Dong, X X and 5 more authors.. (2000) Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:10605003]
31. Pasqualini, R R and 9 more authors.. (2000) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.. Cancer research, (1): [PMID:10676659]
32. Seli, E E, Senturk, L M LM, Bahtiyar, O M OM, Kayisli, U A UA and Arici, A A.. (2001) Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen.. Fertility and sterility, [PMID:11384645]
33. Wentworth, D E DE and Holmes, K V KV.. (2001) Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation.. Journal of virology, [PMID:11559807]
34. van Hensbergen, Yvette Y and 7 more authors.. (2002) Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid.. Clinical cancer research : an official journal of the American Association for Cancer Research, [PMID:12473585]
35. Kristiansen, Troels Zakarias TZ and 8 more authors.. (2004) A proteomic analysis of human bile.. Molecular & cellular proteomics : MCP, [PMID:15084671]
36. Kramer, Werner W and 11 more authors.. (2005) Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane.. The Journal of biological chemistry, (14): [PMID:15494415]
37. Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
38. Zody, Michael C MC and 68 more authors.. (2006) Analysis of the DNA sequence and duplication history of human chromosome 15.. Nature, (30): [PMID:16572171]
39. Bian, Yangyang Y and 9 more authors.. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.. Journal of proteomics, (16): [PMID:24275569]

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CD13 Mouse mAb - Primary antibody, specific to CD13, Mouse IgG1

Basic Description

Product Properties

Images

Associated Targets

ANPEP Tchem Aminopeptidase N 0 Activities

Application

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
Ab093787-10μg (Trial Size) Apply for free trial size（?） Every year, as a valued customer, you have the exclusive opportunity to explore and enjoy three different trial products of your choice, absolutely free!	10μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$26.90
Ab093787-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab093787-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$99.90
Ab093787-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90