CD22 Mouse mAb - Primary antibody, specific to CD22, Mouse IgG1

    Application:
  • Animal Model
  • Depletion
  • Flow Cytometry
  • Functional Assay
  • IP
Features and benefitsView More
  • Host species: Mouse
  • Species reactivity(Reacts with): Mouse
  • Isotype: Mouse IgG1
  • Clone Number: Cy34.1
  • Conjugation: Unconjugated
Item Number
Ab094278
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab094278-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$39.90
Ab094278-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
Ab094278-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$129.90
Ab094278-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$599.90

mAb (Cy34.1); Mouse anti Mouse CD22 Antibody; in vivo B cell depletion in combination with anti-CD19 (clone 1D3) and anti-rat κLight Chain (clone MAR 18.5), Flow, IP; Unconjugated

Basic Description

Product NameCD22 Mouse mAb - Primary antibody, specific to CD22, Mouse IgG1
SynonymsLyb8 | Lyb-8 | A530093D23 | B-cell receptor CD22 | BL-CAM | B-lymphocyte cell adhesion molecule | CD22 antigenMGC130020 | CD22 molecule | CD22 | sialic acid binding Ig-like lectin 2 | Sialic acid-binding Ig-like lectin 2 | Siglec2 | Siglec-2 | SIGLEC2FLJ2
Specifications & PurityCarrier Free, ExactAb™, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host speciesMouse
SpecificityCD22
ImmunogenB10.D2 mouse splenocytes
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Validated
Product Description

Mouse anti Mouse CD22 Antibody, Monoclonal (Cy34.1), could be used for in vivo B cell depletion in combination with anti-CD19 (clone 1D3) and anti-rat κLight Chain (clone MAR 18.5), Flow, IP and so on.
Application:
in vivo B cell depletion in combination with anti-CD19 (clone 1D3) and anti-rat κLight Chain (clone MAR 18.5): Use at an assay dependent concentration. 
Flow: Use at an assay dependent concentration.
IP: Use at an assay dependent concentration. 
Protein Function
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Product Properties

IsotypeMouse IgG1
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein G purified
FormLiquid
ConcentrationSee COA
Storage TempStore at 2-8°C,Freeze prohibited
Shipped InWet ice
Stability And StorageShipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon delivery aliquot.

Images

CD22 Mouse mAb (Ab094278) - Flow Cytometry
Two-color flow cytometric analysis of CD22 expression on mouse splenocytes. C57BL/6 mouse spleen cells were stained with CD3 Rat mAb (FITC) (Ab185406) and either Mouse IgG Isotype Control Antibody (Biotin) (Ab180306; Left panel) or CD22 Mouse mAb (Ab094278; Right panel) at 0.5 μg/mL. Two-color flow cytometric dot plots showing the correlated expression of CD3 versus CD22 (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable mononuclear cells.

Application

ApplicationDilution info
IPUse at an assay dependent concentration.

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Use at an assay dependent concentration.

Flow CytometryUse at an assay dependent concentration.

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Use at an assay dependent concentration.

in vivo B cell depletion in combination with anti-CD19 (clone 1D3) and anti-rat κLight Chain (clone MAR 18.5)

Use at an assay dependent concentration. 

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Enter lot number to search for analytical chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0809290Certificate of AnalysisAug 06, 2024 Ab094278
ZJ24F0809289Certificate of AnalysisAug 06, 2024 Ab094278
ZJ24F0809288Certificate of AnalysisAug 06, 2024 Ab094278

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