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CDK12 inhibitor 2 , CAS No.C608435, Inhibitor of cyclin dependent kinase 12;Inhibitor of cyclin dependent kinase 13;Inhibitor of cyclin dependent kinase 7;Inhibitor of cyclin dependent kinase 8;Inhibitor of cyclin dependent kinase 9

  • Moligand™
Item Number
C608435
Grouped product items
SKUSizeAvailabilityPrice Qty
C608435-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
C608435-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$759.90
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View related series
cyclin dependent kinase 12 Inhibitor cyclin dependent kinase 13 Inhibitor cyclin dependent kinase 7 Inhibitor cyclin dependent kinase 8 Inhibitor cyclin dependent kinase 9 Inhibitor

Basic Description

GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of cyclin dependent kinase 12;Inhibitor of cyclin dependent kinase 13;Inhibitor of cyclin dependent kinase 7;Inhibitor of cyclin dependent kinase 8;Inhibitor of cyclin dependent kinase 9

Associated Targets

CDK13 Tchem Cyclin-dependent kinase 13 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK7 Tchem Cyclin-dependent kinase 7 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK9 Tchem Cyclin-dependent kinase 9 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK8 Tchem Cyclin-dependent kinase 8 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK12 Tchem Cyclin-dependent kinase 12 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)urea
INCHI InChI=1S/C32H32N6O2/c1-37-22-26(10-18-31(37)39)25-8-13-28(14-9-25)38(32(40)35-20-23-5-3-2-4-6-23)29-15-11-27(12-16-29)36-30-17-7-24(19-33)21-34-30/h2-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,1H3,(H,34,36)(H,35,40)/t27-,29-
InChi Key HDJBGURZVALLMD-KWQFAZJVSA-N
Canonical SMILES N#Cc1ccc(nc1)N[C@@H]1CC[C@H](CC1)N(c1ccc(cc1)c1ccc(=O)n(c1)C)C(=O)NCc1ccccc1
Isomeric SMILES CN1C=C(C=CC1=O)C2=CC=C(C=C2)N(C3CCC(CC3)NC4=NC=C(C=C4)C#N)C(=O)NCC5=CC=CC=C5
PubChem CID 134813906

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. CDK12-IN-2
    CDK12-IN-2

    Starting at $385.90

References

1. Ito M, Tanaka T, Toita A, Uchiyama N, Kokubo H, Morishita N, Klein MG, Zou H, Murakami M, Kondo M et al..  (2018)  Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors..  J Med Chem,  61  (17): (7710-7728).  [PMID:30067358]

Solution Calculators

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