CE-245677 - 98%, high purity , CAS No.717899-97-3

Item Number

C646954

Grouped product items
SKU	Size	Availability	Price
C646954-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$71.90
C646954-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
C646954-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
C646954-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
C646954-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90

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Basic Description

Synonyms	CE-245677\|717899-97-3\|UNII-GMH17J9LHL\|GMH17J9LHL\|CE 245677 [WHO-DD]\|1-(5-(4-Amino-7-isopropyl-pyrrolo(2,3-d)pyrimidine-5-carbonyl)-2-methoxy-phenyl)-3-(2,4-dichlorophenyl)urea\|Urea, N-(5-((4-amino-7-(1-methylethyl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)carbonyl
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 s of 4.7 and 1 nM. In Vitro CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC 50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TrkA Tie2 4.7 nM (IC 50 )

Names and Identifiers

IUPAC Name	1-[5-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxyphenyl]-3-(2,4-dichlorophenyl)urea
INCHI	InChI=1S/C24H22Cl2N6O3/c1-12(2)32-10-15(20-22(27)28-11-29-23(20)32)21(33)13-4-7-19(35-3)18(8-13)31-24(34)30-17-6-5-14(25)9-16(17)26/h4-12H,1-3H3,(H2,27,28,29)(H2,30,31,34)
InChi Key	VFCRSIORGUNNGT-UHFFFAOYSA-N
Canonical SMILES	CC(C)N1C=C(C2=C(N=CN=C21)N)C(=O)C3=CC(=C(C=C3)OC)NC(=O)NC4=C(C=C(C=C4)Cl)Cl
Isomeric SMILES	CC(C)N1C=C(C2=C(N=CN=C21)N)C(=O)C3=CC(=C(C=C3)OC)NC(=O)NC4=C(C=C(C=C4)Cl)Cl
Alternate CAS	717899-97-3
PubChem CID	16048643
Molecular Weight	513.4

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Basic Description