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Cebranopadol - ≥98%, high purity , CAS No.863513-91-1, Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor;Agonist of NOP receptor

  • Moligand™
  • ≥98%
Item Number
C126216
Grouped product items
SKUSizeAvailabilityPrice Qty
C126216-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90
C126216-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$206.90
C126216-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$513.90

Basic Description

SynonymsCebranopadol|863513-91-1|GRT6005|GRT-6005|GRT 6005|863513-93-3|Cebranopadol ((1alpha,4alpha)stereoisomer)|Cebranopadol(GRT-6005)|7GDW9S3GN3|863513-91-1 (free base)|(1r,4r)-6'-Fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor;Agonist of NOP receptor

Associated Targets

OPRD1 Tclin Delta-type opioid receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRL1 Tchem Nociceptin receptor 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OGFRL1 Tchem Opioid growth factor receptor-like protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine
INCHI InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3
InChi Key CSMVOZKEWSOFER-UHFFFAOYSA-N
Canonical SMILES CN(C)C1(CCC2(CC1)C3=C(CCO2)C4=C(N3)C=CC(=C4)F)C5=CC=CC=C5
Isomeric SMILES CN(C)C1(CCC2(CC1)C3=C(CCO2)C4=C(N3)C=CC(=C4)F)C5=CC=CC=C5
PubChem CID 11848225
Molecular Weight 378.48

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO

Related Documents

References

1. Linz K, Christoph T, Tzschentke TM, Koch T, Schiene K, Gautrois M, Schröder W, Kögel BY, Beier H, Englberger W et al..  (2014)  Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist..  J Pharmacol Exp Ther,  349  (3): (535-48).  [PMID:24713140]
2. Schunk S, Linz K, Hinze C, Frormann S, Oberbörsch S, Sundermann B, Zemolka S, Englberger W, Germann T, Christoph T et al..  (2014)  Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol..  ACS Med Chem Lett,  (8): (857-62).  [PMID:25147603]
3. Lambert DG, Bird MF, Rowbotham DJ.  (2015)  Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist..  Br J Anaesth,  114  (3): (364-6).  [PMID:25248647]
4. Sałat K, Jakubowska A, Kulig K.  (2015)  Cebranopadol : a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors..  Expert Opin Investig Drugs,  24  (6): (837-44).  [PMID:25865744]
5. Bird MF, Lambert DG.  (2015)  Simultaneous targeting of multiple opioid receptor types..  Curr Opin Support Palliat Care,  (2): (98-102).  [PMID:25872121]

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