Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C380688-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $85.90 | |
C380688-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $265.90 |
an inhibitor of CDK1/cyclin B, PKCα, PKA, and EGFR
Synonyms | CGP74514A|190653-73-7|CGP-74514|CGP 74514A|9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-|CGP-74514A|7LQ52UF48A|CHEMBL367625|2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine|9H-Purine-2,6-dia |
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Specifications & Purity | Moligand™, ≥95% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 4;Inhibitor of cyclin dependent kinase 5;Inhibitor of cyclin dependent kinase 7;Inhibitor of cyclin dependent kinase 9 |
Product Description | CGP 74514A is a cell permeable, potent, and selective inhibitor of CDK1/cyclin B (IC|50|= 25 nM). CGP 74514A is reported to affect the activities of other kinases only at much higher concentrations, such as PKCα (IC|50|= 6.1 μM), PKA (IC|50|= 125 μM) and EGFR (IC|50|> 10 μM). CGP 74514A induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3μM). |
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Canonical SMILES | CCN1C=NC2=C1N=C(N=C2NC3=CC(=CC=C3)Cl)N[C@@H]4CCCC[C@@H]4N |
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Isomeric SMILES | CCN1C=NC2=C(N=C(N=C21)N[C@@H]3CCCC[C@@H]3N)NC4=CC(=CC=C4)Cl |
PubChem CID | 2794188 |
Molecular Weight | 385.89 |
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Solubility | Soluble in DMSO (10 mg/ml). |
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1. Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J. (1999) 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.. Bioorg Med Chem Lett, 9 (1): (91-6). [PMID:9990463] |