CGRP(hu,Mod Asp3 to Pra)，TFA salt - ≥95%, high purity , CAS No.C276414

Item Number

C276414

Grouped product items
SKU	Size	Availability	Price	Qty
C276414-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$171.90
C276414-5mg	5mg	In stock	$769.90

Endogenous vasodilatory neuropeptide.

Basic Description

Specifications & Purity	≥95%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Product Description	Shipped at 4°C. Store at -20°C. Store under desiccating conditions. CGRP (hu, Mod Asp3 to Pra) TFA salt is a 37 amino acid neuroendocrine hormone that belongs to the calcitonin (CT) family. It is a vasodilator and plays an important role in neurogenic inflammation, and therefore has gained significant interest for the treatment of migraine. CGRP exerts effects through the CGRP receptor. To probe receptor binding, labelling with TAMRA azide, 5- isomer, Orange emitting fluorescent dye (ab146486), using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) to position 3 of human αCGRP, generates a potent fluorescent CGRP.

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2 results found

Lot Number	Certificate Type	Date	Item
L2209015	Certificate of Analysis	Sep 21, 2023	C276414
K2202334	Certificate of Analysis	Aug 04, 2023	C276414

References

1. Eftekhari S & Edvinsson L. (2011) Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.. BMC Neurosci, 12 (112). [PMID:22074408]
2. Durham PL. (2006) Calcitonin gene-related peptide (CGRP) and migraine.. Headache, 46 Suppl 1 (S3-8). [PMID:16927957]
3. Durham PL & Vause CV. (2010) Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.. CNS Drugs, 24 (7): (539-48). [PMID:20433208]

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Basic Description