Skip to the beginning of the images gallery

CGS8216 , CAS No.77779-60-3, Agonist of GABA A receptor α1 subunit;Agonist of GABA A receptor α2 subunit;Agonist of GABA A receptor α3 subunit;Agonist of GABA A receptor α5 subunit;Agonist of GABA A receptor α6 subunit

Moligand™

CAS#: 77779-60-3
PubChem CID: 104916

Item Number

C608517

Grouped product items
SKU	Size	Availability	Price	Qty
C608517-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$370.90
C608517-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90

View related series

GABAA receptor α1 subunit Agonist GABAA receptor α2 subunit Agonist GABAA receptor α3 subunit Agonist GABAA receptor α5 subunit Agonist GABAA receptor α6 subunit Agonist

Basic Description

Synonyms	77779-60-3\|CGS-8216\|CGS8216\|Cgs 8216\|2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one\|2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one\|YXH2C8E92N\|2-phenyl-1,2-dihydro-3h-pyrazolo[4,3-c]quinolin-3-one\|2-phenyl-1H,2H,3H-pyrazolo[4,3-c]quinolin-3-one\|2,5-Dihydro-2-phe
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GABA A receptor α1 subunit;Agonist of GABA A receptor α2 subunit;Agonist of GABA A receptor α3 subunit;Agonist of GABA A receptor α5 subunit;Agonist of GABA A receptor α6 subunit

Associated Targets

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 2 Activities

Discover Target: GABRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA3 Tclin Gamma-aminobutyric acid receptor subunit alpha-3 1 Activities

Discover Target: GABRA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA5 Tclin Gamma-aminobutyric acid receptor subunit alpha-5 2 Activities

Discover Target: GABRA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA2 Tclin Gamma-aminobutyric acid receptor subunit alpha-2 1 Activities

Discover Target: GABRA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA6 Tclin Gamma-aminobutyric acid receptor subunit alpha-6 1 Activities

Discover Target: GABRA6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-phenyl-1H,2H,3H-pyrazolo[4,3-c]quinolin-3-one
INCHI	InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,18H
InChi Key	XTYGFVVANLMBHE-UHFFFAOYSA-N
Canonical SMILES	O=c1n([nH]c2c1cnc1c2cccc1)c1ccccc1
Isomeric SMILES	C1=CC=C(C=C1)N2C(=O)C3=C(N2)C4=CC=CC=C4N=C3
PubChem CID	104916

PubChem CID

Wikipedia

CAS Registry No.

ChEMBL Ligand

References

1. Huang Q, He X, Ma C, Liu R, Yu S, Dayer CA, Wenger GR, McKernan R, Cook JM. (2000) Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.. J Med Chem, 43 (1): (71-95). [PMID:10633039]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.