Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C275315-5mg | 5mg | In stock | $58.90 | |
C275315-10mg | 10mg | In stock | $94.90 | |
C275315-25mg | 25mg | In stock | $213.90 | |
C275315-50mg | 50mg | In stock | $379.90 | |
C275315-100mg | 100mg | In stock | $684.90 |
Potent, ATP-competitive checkpoint kinase (Chhk) 2 inhibitor. Cell-permeable.
Synonyms | BML-277|516480-79-8|Chk2 Inhibitor II|2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide|ML-277 (Chk2 Inhibitor II)|BML277|CHEMBL179583|2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide|2-(4-(4-chlorophenoxy)phenyl)-1H-benzo[d]imidazo |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, ATP-competitive checkpoint kinase 2 inhibitor (IC 50 = 15 nM; K i = 37 nM). Controls p53 response to DNA breaks. leading to apoptosis. Cell-permeable. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of checkpoint kinase 2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide |
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INCHI | InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) |
InChi Key | UXGJAOIJSROTTN-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl |
Isomeric SMILES | C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl |
PubChem CID | 9969021 |
Molecular Weight | 363.8 |
PubChem CID | 9969021 |
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ChEMBL Ligand | CHEMBL179583 |
CAS Registry No. | 516480-79-8 |
RCSB PDB Ligand | RU5 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2206473 | Certificate of Analysis | May 12, 2023 | C275315 |
H2206480 | Certificate of Analysis | May 12, 2023 | C275315 |
H2206481 | Certificate of Analysis | May 12, 2023 | C275315 |
H2206483 | Certificate of Analysis | May 12, 2023 | C275315 |
H2206484 | Certificate of Analysis | May 12, 2023 | C275315 |
Solubility | Soluble in DMSO to 25 mM |
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1. Dai CH et al.. (2017) Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine.. Sci Rep, 7 (15031). [PMID:29118324] |