| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C100332-250mg | 250mg | In stock | $101.90 |
Broad spectrum antibiotic agent
| Synonyms | chloramphenicol|56-75-7|Chloromycetin|Chlornitromycin|Levomycetin|Chloroamphenicol|Globenicol|Halomycetin|Levomicetina|Oleomycetin|Alficetyn|Chloramex|Chlorocid|Chlorocol|Fenicol|Chloramficin|Chloramfilin|Enteromycetin|Amphicol|Aquamycetin|Chloroptic|Clor |
|---|---|
| Specifications & Purity | Moligand™, analytical standard |
| Biochemical and Physiological Mechanisms | Broad spectrum antibiotic agent. Binds selectively to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal subunit. Prevents peptide bond formation and protein chain elongation inhibiting protein biosynthesis. Shows bacteriostatic effects against |
| Storage Temp | Protected from light,Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Grade | analytical standard, Moligand™ |
| Action Type | AGONIST |
| Mechanism of action | Agonist of TAS2R41;Agonist of TAS2R8 |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Chloramphenicol is a potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research. |
| ALogP | 1.1 |
|---|
| IUPAC Name | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide |
|---|---|
| INCHI | InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1 |
| InChi Key | WIIZWVCIJKGZOK-RKDXNWHRSA-N |
| Canonical SMILES | C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-] |
| Isomeric SMILES | C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-] |
| WGK Germany | 3 |
| RTECS | AB6825000 |
| PubChem CID | 5959 |
| Molecular Weight | 323.13 |
| Beilstein | 2225532 |
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| Sensitivity | light sensitive |
|---|---|
| Specific Rotation[α] | 20 ° (C=5, EtOH) |
| Flash Point(°F) | 57.2°F closed cup |
| Flash Point(°C) | 14.0°C closed cup |
| Melt Point(°C) | 149-153°C |
| Pictogram(s) | GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H351:Suspected of causing cancer H318:Causes serious eye damage H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child H350:May cause cancer H361:Suspected of damaging fertility or the unborn child |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
| WGK Germany | 3 |
| RTECS | AB6825000 |
| Merck Index | 2077 |
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