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Chloramphenicol succinate sodium salt - ≥80% (HPLC), high purity , Bacterial 70S ribosome inhibitor, CAS No.982-57-0, Bacterial 70S ribosome inhibitor

  • ≥80%(HPLC)
Item Number
C463077
Grouped product items
SKUSizeAvailabilityPrice Qty
C463077-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$152.90
C463077-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$606.90
C463077-100g
100g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,651.90
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Basic Description

SynonymsCHLORAMPHENICOL SODIUM SUCCINATE|982-57-0|Chloramphenicol succinate sodium|Protophenicol|Mychel-s|Chloramphenicol monosuccinate sodium salt|Sodium chloramphenicol succinate|Chloramphenicol sodium monosuccinate|CCRIS 6204|Chloramphenicol-sukzinat-natrium|C
Specifications & Purity≥80% (HPLC)
Action TypeINHIBITOR
Mechanism of actionBacterial 70S ribosome inhibitor
Product Description

Description

Chemical structure: phenicoleChloramphenicol is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.


Preparation instructions

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Names and Identifiers

IUPAC Name sodium;4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate
INCHI InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1
InChi Key RPLOPBHEZLFENN-HTMVYDOJSA-M
Canonical SMILES C1=CC(=CC=C1C(C(COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
Isomeric SMILES C1=CC(=CC=C1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
PubChem CID 656833
Molecular Weight 445.19

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility H2O: 50mg/mL
Melt Point(°C)>42ºC

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements

H351:Suspected of causing cancer

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

Related Documents

 SDS

 Specification Sheet

References

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18. T I Ti,E H Monteiro,S Lam,H S Lee.  (1990-09-01)  Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation..  Antimicrobial agents and chemotherapy,  34  ((9)): (1809-1811).  [PMID:2285296]
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21. M Ashton,P Bolme,E Alemayehu,M Eriksson,L Paalzow.  (1993-01-01)  Decreased chloramphenicol clearance in malnourished Ethiopian children..  European journal of clinical pharmacology,  45  ((2)): (181-186).  [PMID:8223842]
22. M C Nahata.  (1993-08-01)  Simultaneous measurement of chloramphenicol sodium succinate and chloramphenicol in presence of furosemide in plasma and urine..  Journal of clinical pharmacy and therapeutics,  18  ((4)): (301-301).  [PMID:8227239]
23. J R Moraes,F R Moraes,G H Bechara.  (1993-05-01)  Participation of macrophages in chloramphenicol-potentiated carrageenin-induced peritonitis in rats..  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,  26  ((5)): (497-507).  [PMID:8257939]
24. C S Ambekar,B Cheung,J Lee,L C Chan,R Liang,C R Kumana.  (2000-09-29)  Metabolism of chloramphenicol succinate in human bone marrow..  European journal of clinical pharmacology,  56  ((5)): (405-409).  [PMID:11009050]
25. J A Turton,C M Andrews,A C Havard,T C Williams.  (2003-03-19)  Studies on the haemotoxicity of chloramphenicol succinate in the Dunkin Hartley guinea pig..  International journal of experimental pathology,  83  ((5)): (225-238).  [PMID:12641819]
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29. John A Turton,Rajni Fagg,William R Sones,Thomas C Williams,C Michael Andrews.  (2006-04-21)  Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse..  International journal of experimental pathology,  87  ((2)): (101-112).  [PMID:16623754]

Solution Calculators

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