Basic Description

Synonyms	Chlorhexidine dihydrochloride\|CHLORHEXIDINE HYDROCHLORIDE\|3697-42-5\|Chlorhexidine HCl\|Arlacide H\|Caswell No. 481F\|Dantroche hibitane\|Chlorhexidinium dichloride\|chlorhexidine\|AY-5312\|EINECS 223-026-6\|UNII-E64XL9U38K\|EPA Pesticide Chemical Code 481700\|Chlor
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Antiseptic effective against a wide variety of gram-negative and gram-positive organisms, used in antiseptics and dental products. Bacteriostatic and bactericidal activity due to outer bacterial membrane disruption.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Chlorhexidine, Dihydrochloride is an anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9 metalloproteinases. However, MMP-2 is more sensitive to chlorhexidine than MMP-9. Chlorhexidine dihydrochloride inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. Chlorhexidine dihydrochloride may possibly act through a cation-chelating mechanism.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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RORC Tchem Nuclear receptor ROR-gamma 0 Activities

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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SMN1 Tchem Survival motor neuron protein 0 Activities

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USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 0 Activities

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POLK Tbio DNA polymerase kappa 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

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HSPA5 Tchem Endoplasmic reticulum chaperone BiP 0 Activities

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BLM Tchem Bloom syndrome protein 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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IMPA1 Tclin Inositol monophosphatase 1 0 Activities

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TP53 Tchem Cellular tumor antigen p53 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

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Names and Identifiers

IUPAC Name	(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride
INCHI	InChI=1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H
InChi Key	WJLVQTJZDCGNJN-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.Cl.Cl
Isomeric SMILES	C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl.Cl.Cl
WGK Germany	3
RTECS	XA5285000
PubChem CID	9571016
Molecular Weight	578.37
Reaxy-Rn	3850979

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
A1625241	Certificate of Analysis	Aug 11, 2023	C113898
I2227080	Certificate of Analysis	Jul 22, 2022	C113898
I2227081	Certificate of Analysis	Jul 22, 2022	C113898

Chemical and Physical Properties

Melt Point(°C)	255-262°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H411:Toxic to aquatic life with long lasting effects H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	XA5285000
Reaxy-Rn	3850979
Merck Index	2091

References

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61. Damian Cordoba Diaz,Ricardo Becerro de Bengoa Vallejo,Marta Elena Losa Iglesias,Manuel Cordoba Diaz. (2013-05-04) Alcohol plus chlorhexidine is more efficient than alcohol alone for phenol-based chemical matricectomy: an in vitro study.. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39 ((9)): (1363-1367). [PMID:23639043]
62. Mary Wilson. (2013-06-12) Catheter lubrication and fixation: interventions.. British journal of nursing (Mark Allen Publishing), 22 ((10)): (566-566). [PMID:23752454]
63. Michael W Climo,Edward S Wong. (2013-06-14) Daily chlorhexidine bathing and hospital-acquired infection.. The New England journal of medicine, 368 ((24)): (2332-2332). [PMID:23758244]
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SKU	Size	Availability	Price
C113898-5g	5g	In stock	$48.90
C113898-25g	25g	In stock	$115.90
C113898-100g	100g	In stock	$417.90

Chlorhexidine dihydrochloride - 98%, high purity , CAS No.3697-42-5