Grouped product items

SKU

Size

Availability

Price

Qty

C109402-250mg

250mg

In stock

$24.90

C109402-1g

In stock

$69.90

C109402-5g

In stock

$239.90

C109402-10g

10g

In stock

$389.90

C109402-25g

25g

Available within 4-8 weeks(?)

$779.90

Basic Description

Synonyms	CHLOROGENIC ACID\|327-97-9\|3-O-Caffeoylquinic acid\|Heriguard\|Chlorogenate\|3-(3,4-Dihydroxycinnamoyl)quinic acid\|3-Caffeoylquinic acid\|Hlorogenic acid\|trans-Chlorogenic acid\|CP chlorogenic acid\|Caffeoyl quinic acid\|Chlorogenicacid\|NSC-407296\|5-CQA\|(+)-Chlor
Specifications & Purity	Moligand™, ≥95%
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein tyrosine phosphatase non-receptor type 1

Associated Targets

DUSP3 Tchem Dual specificity protein phosphatase 3 0 Activities

Discover Target: DUSP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN2 Tchem Tyrosine-protein phosphatase non-receptor type 2 0 Activities

Discover Target: PTPN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 0 Activities

Discover Target: PTPN11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 1 Activities

Discover Target: PTPN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN6 Tchem Tyrosine-protein phosphatase non-receptor type 6 0 Activities

Discover Target: PTPN6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

Discover Target: SRC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 0 Activities

Discover Target: RAPGEF3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 0 Activities

Discover Target: RAPGEF4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT3 Tchem Signal transducer and activator of transcription 3 0 Activities

Discover Target: STAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT1 Tchem Signal transducer and activator of transcription 1-alpha/beta 0 Activities

Discover Target: STAT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT5B Tchem Signal transducer and activator of transcription 5B 0 Activities

Discover Target: STAT5B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC37A4 Tchem Glucose-6-phosphate exchanger SLC37A4 0 Activities

Discover Target: SLC37A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 0 Activities

Discover Target: UGT1A9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TTR Tclin Transthyretin 0 Activities

Discover Target: TTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LPO Tbio Lactoperoxidase 0 Activities

Discover Target: LPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LCK Tclin Tyrosine-protein kinase Lck 0 Activities

Discover Target: LCK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B10 Tchem Aldo-keto reductase family 1 member B10 0 Activities

Discover Target: AKR1B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 1 Activities

Discover Target: AKR1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein 0 Activities

Discover Target: APP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 0 Activities

Discover Target: UGT1A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2 Tclin Prothrombin 0 Activities

Discover Target: F2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Discover Target: BCHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

Discover Target: GLS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLA2G7 Tchem Platelet-activating factor acetylhydrolase 0 Activities

Discover Target: PLA2G7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid
INCHI	InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1
InChi Key	CWVRJTMFETXNAD-JUHZACGLSA-N
Canonical SMILES	O[C@@H]1C[C@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)C(O)=O
Isomeric SMILES	C1[C@H]([C@H]([C@@H](C[C@@]1(C(=O)O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O
WGK Germany	3
PubChem CID	1794427
Molecular Weight	354.31

Database links

PubChem CID	1794427
CAS Registry No.	327-97-9
ChEMBL Ligand	CHEMBL284616
ChEBI	CHEBI:16112
BindingDB Ligand	13080

Certificates

Certificate of Analysis(COA)

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28 results found

Lot Number	Certificate Type	Date	Item
H2413422	Certificate of Analysis	Aug 21, 2024	C109402
H2413421	Certificate of Analysis	Aug 21, 2024	C109402
H2413420	Certificate of Analysis	Aug 21, 2024	C109402
H2413419	Certificate of Analysis	Aug 21, 2024	C109402
E2413220	Certificate of Analysis	May 17, 2024	C109402
E2413223	Certificate of Analysis	May 17, 2024	C109402
G2401045	Certificate of Analysis	May 17, 2024	C109402
E2413224	Certificate of Analysis	May 17, 2024	C109402
E2413199	Certificate of Analysis	May 17, 2024	C109402
J2330332	Certificate of Analysis	Nov 02, 2023	C109402
J2330331	Certificate of Analysis	Nov 02, 2023	C109402
J2330330	Certificate of Analysis	Nov 02, 2023	C109402
J2330311	Certificate of Analysis	Nov 02, 2023	C109402
H2325320	Certificate of Analysis	Aug 31, 2023	C109402
H2325322	Certificate of Analysis	Aug 31, 2023	C109402
H2325321	Certificate of Analysis	Aug 31, 2023	C109402
H2325319	Certificate of Analysis	Aug 31, 2023	C109402
H2325318	Certificate of Analysis	Aug 31, 2023	C109402
H2325317	Certificate of Analysis	Aug 31, 2023	C109402
H2325289	Certificate of Analysis	Aug 31, 2023	C109402
H2325288	Certificate of Analysis	Aug 31, 2023	C109402
H2325287	Certificate of Analysis	Aug 31, 2023	C109402
G2308176	Certificate of Analysis	Jul 13, 2023	C109402
L2210436	Certificate of Analysis	Dec 16, 2022	C109402
L2210438	Certificate of Analysis	Dec 16, 2022	C109402
G2220471	Certificate of Analysis	Jan 12, 2022	C109402
G2220470	Certificate of Analysis	Jan 12, 2022	C109402
J2113510	Certificate of Analysis	Oct 18, 2021	C109402

Chemical and Physical Properties

Solubility	Soluble in water; Very soluble in Acetone,Alcohol
Specific Rotation[α]	-37 ° (C=1, H2O)
Melt Point(°C)	210°C

Safety and Hazards(GHS)

WGK Germany	3
Merck Index	2142

FAQs and Articles

FAQ

Targeted drug discovery: scarce and inefficient, what is the geometry of its effectiveness?

Categories: Technical articles

Tags:

Targeted drug Drug discovery Discovery origin Target-based drug Phenotype-based drugs

References

1. Selenge E, Murata T, Kobayashi K, Batkhuu J, Yoshizaki F. (2013) Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian medicinal plant Dracocephalum ruyschiana.. J Nat Prod, 76 (2): (186-93). [PMID:23356964]
2. Murai T, Matsuda S. (2023) The Chemopreventive Effects of Chlorogenic Acids, Phenolic Compounds in Coffee, against Inflammation, Cancer, and Neurological Diseases.. Molecules, 28 (5): (589-97). [PMID:36903626]
3. Hibi M. (2023) Potential of Polyphenols for Improving Sleep: A Preliminary Results from Review of Human Clinical Trials and Mechanistic Insights.. Nutrients, 15 (5): (589-97). [PMID:36904255]

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Chlorogenic acid - 95%, high purity , CAS No.327-97-9, Inhibitor of protein tyrosine phosphatase non-receptor type 1

Basic Description

Associated Targets

DUSP3 Tchem Dual specificity protein phosphatase 3 0 Activities

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

GMNN Tbio Geminin 0 Activities

PTPN2 Tchem Tyrosine-protein phosphatase non-receptor type 2 0 Activities

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 0 Activities

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 1 Activities

PTPN6 Tchem Tyrosine-protein phosphatase non-receptor type 6 0 Activities

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 0 Activities

RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 0 Activities

STAT3 Tchem Signal transducer and activator of transcription 3 0 Activities

STAT1 Tchem Signal transducer and activator of transcription 1-alpha/beta 0 Activities

STAT5B Tchem Signal transducer and activator of transcription 5B 0 Activities

SLC37A4 Tchem Glucose-6-phosphate exchanger SLC37A4 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 0 Activities

TTR Tclin Transthyretin 0 Activities

LPO Tbio Lactoperoxidase 0 Activities

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

LCK Tclin Tyrosine-protein kinase Lck 0 Activities

ACHE Tclin Acetylcholinesterase 0 Activities

AKR1B10 Tchem Aldo-keto reductase family 1 member B10 0 Activities

AKR1B1 Tclin Aldose reductase 1 Activities

APP Tclin Amyloid-beta A4 protein 0 Activities

UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 0 Activities

F2 Tclin Prothrombin 0 Activities

BCHE Tclin Cholinesterase 0 Activities

GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities

PLA2G7 Tchem Platelet-activating factor acetylhydrolase 0 Activities

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator