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Chlorotrimethylsilane solution - 1.0 M in THF, high purity , CAS No.75-77-4(THF)

  • 1.0 M in THF
Item Number
C433634
Grouped product items
SKUSizeAvailabilityPrice Qty
C433634-100ml
100ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$49.90
View related series
Silanes

Basic Description

SynonymsChlorotrimethylsilane|75-77-4|TRIMETHYLCHLOROSILANE|Trimethylsilyl chloride|chloro(trimethyl)silane|Silane, chlorotrimethyl-|Trimethyl chlorosilane|Monochlorotrimethylsilicon|TMCS|Silane, trimethylchloro-|Silicane, chlorotrimethyl-|TMSCl|Silylium, trimeth
Specifications & Purity1.0 M in THF
Storage TempArgon charged
Shipped InNormal
Note干的残留物是爆炸性的。 定期/蒸馏前检测过氧化物的生成。
Product Description

Chlorotrimethylsilane (TMSCl) is a silylating agent employed in the silylation of alcohols, amines, carboxylic acids, thiols, and other functional groups. Silyl group serves as a protecting group for these original functional groups.
Application:
Chlorotrimethylsilane (TMSCl) can be used as a reagent:
To synthesize allenylsilane via carbolithiation of conjugated enynes with aryllithium.
In the reductive coupling of aldehydes and ketones to produce corresponding 1,2 diols in the presence of zirconocene dichloride and magnesium.
To prepare 4,4′-bis(trimethylsilyl)bicyclohexyl-2,2′-diene from 1,3-cyclohexadiene by reductive disilylation reaction.

Associated Targets

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name chloro(trimethyl)silane
INCHI InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
InChi Key IJOOHPMOJXWVHK-UHFFFAOYSA-N
Canonical SMILES C[Si](C)(C)Cl
Isomeric SMILES C[Si](C)(C)Cl
WGK Germany 2
RTECS VV2710000
PubChem CID 6397
UN Number 2924
Packing Group II
Molecular Weight 108.64
Beilstein 1209232

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
H2406417Certificate of AnalysisAug 14, 2024 C433634

Chemical and Physical Properties

Refractive Index1.3884

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS05,   GHS07,   GHS02
Signal Danger
Hazard Statements

H335:May cause respiratory irritation

H351:Suspected of causing cancer

H314:Causes severe skin burns and eye damage

H302:Harmful if swallowed

H225:Highly Flammable liquid and vapor

H336:May cause drowsiness or dizziness

H371:May cause damage to organs

H333:May be harmful if inhaled

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378:In case of fire: Use ... to extinguish.

P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.

P405:Store locked up.

P501:Dispose of contents/container to ...

P233:Keep container tightly closed.

P240:Ground/bond container and receiving equipment.

P264:Wash hands [and …] thoroughly after handling.

P403+P235:Store in a well-ventilated place. Keep cool.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower].

P201:Obtain special instructions before use.

P271:Use only outdoors or in a well-ventilated area.

P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment.

P270:Do not eat, drink or smoke when using this product.

P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363:Wash contaminated clothing before reuse.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P308+P311:IF exposed or concerned: Call a POISON CENTER/doctor/...

P202:Do not handle until all safety precautions have been read and understood.

P242:Use only non-sparking tools.

P243:Take precautionary measures against static discharge.

P301+P312+P330:IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.

WGK Germany 2
RTECS VV2710000
Class 3 / 8

Related Documents

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