Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C130186-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $309.90 | |
C130186-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,029.90 |
Bile acid precursor. Displays pro-inflammatory activity.
Synonyms | 7alpha-Hydroxycholesterol|566-26-7|Cholest-5-en-3beta,7alpha-diol|Cholest-5-ene-3beta,7alpha-diol|7-alpha-Hydroxycholesterol|7alpha-hydroxy-cholesterol|5-CHOLESTEN-3-BETA, 7-ALPHA-DIOL|7|A-hydroxycholesterol|(3S,7S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Bile acid precursor produced by cholesterol 7 alpha-hydroxylase. Induces inflammation by enhancing production of chemokine (C-C motif) ligand 2. Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of GPR183 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A secondary metabolite of Cholesterol. |
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IUPAC Name | (3S,7S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol |
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INCHI | InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1 |
InChi Key | OYXZMSRRJOYLLO-RVOWOUOISA-N |
Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C |
Isomeric SMILES | C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C |
PubChem CID | 107722 |
Molecular Weight | 402.653 |
CAS Registry No. | 566-26-7 |
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PubChem CID | 107722 |
ChEBI | CHEBI:17500 |
ChEMBL Ligand | CHEMBL497207 |
Wikipedia | 7?-Hydroxycholesterol |
RCSB PDB Ligand | 5JK |
GPCRdb Ligand | 7α-hydroxycholesterol |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D1917037 | Certificate of Analysis | Dec 08, 2022 | C130186 |
Solubility | Soluble in Chloroform |
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Sensitivity | Moisture sensitive |