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Cholesteryl chloroformate - 95%, high purity , CAS No.7144-08-3

23 Citations

≥95%

CAS#: 7144-08-3
Formula: C₂₈H₄₅ClO₂
Molecular Weight: 449.11
Beilstein Registry Number: 3223154
EC Number: 230-447-9
MDL number: MFCD00003633
PubChem CID: 111262
PubChem SID: 488187466

Item Number

C498284

Grouped product items
SKU	Size	Availability	Price	Qty
C498284-5g	5g	In stock	$38.90
C498284-25g	25g	In stock	$133.90

View related series

Cholesteric liquid crystals Cholesterol-based compound [liquid crystal (LC) material] Liquid Crystal (LC) Materials

Basic Description

Synonyms	Cholesterol chloroformate \| Chloroformic Acid Cholesterol Ester
Specifications & Purity	≥95%
Storage Temp	Argon charged
Shipped In	Normal
Product Description	Application: initiator

Names and Identifiers

Pubchem Sid	488187466
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488187466
IUPAC Name	[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] carbonochloridate
INCHI	InChI=1S/C28H45ClO2/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-26(29)30)13-15-27(20,4)25(22)14-16-28(23,24)5/h9,18-19,21-25H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,27+,28-/m1/s1
InChi Key	QNEPTKZEXBPDLF-JDTILAPWSA-N
Canonical SMILES	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)Cl)C)C
Isomeric SMILES	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)Cl)C)C
WGK Germany	3
PubChem CID	111262
UN Number	3261
Molecular Weight	449.11
Beilstein	3223154

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
G2431169	Certificate of Analysis	Jul 19, 2024	C498284
G2431188	Certificate of Analysis	Jul 19, 2024	C498284
B2317565	Certificate of Analysis	Feb 24, 2023	C498284
B2317583	Certificate of Analysis	Feb 24, 2023	C498284

Chemical and Physical Properties

Solubility	Soluble in water (reacts).
Sensitivity	Sensitive to humidity
Specific Rotation[α]	-23 ° (C=2, THF)
Melt Point(°C)	116-118°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately.
WGK Germany	3

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Wang Yanzhi, Wang Linchao, Chang Hanyue, Shen Qing, Zhang Sai, Sun Shanshan, Liu Ying, Zheng Jiaxin, Liu Hongmin. (2023) Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence. Drug Delivery and Translational Research, (16): (1-14). [PMID:37755673] [10.1007/s13346-023-01433-5]
2. Yina Zhang, Liying Wang, Jiajia Shao, Yanning Liu, Yining Lu, Jing Yang, Siduo Xu, Jingkang Zhang, Minwei Li, Xiangrui Liu, Min Zheng. (2023) Nano-calcipotriol as a potent anti-hepatic fibrosis agent. MedComm, 4 (5): (e354). [PMID:37638336] [10.1002/mco2.354]
3. Danrong Hu, Omar Mezghrani, Lei Zhang, Yi Chen, Xue Ke, Tianyuan Ci. (2023) GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy. International Journal of Nanomedicine, [PMID:27785019] [10.2147/IJN.S113469]
4. Wenzhu Yin, Bihua Deng, Zeyu Xu, Haiyan Wang, Fang Ma, Mingxu Zhou, Yu Lu, Jinqiu Zhang. (2023) Formulation and Evaluation of Lipidized Imiquimod as an Effective Adjuvant. ACS Infectious Diseases, 9 (2): (378–387). [PMID:36688646] [10.1021/acsinfecdis.2c00583]
5. Hong Zhai, Kaibin Chen, Yue Meng, Zejia Wu, Rongli Deng, Ying Bai, Jing Zhou, Daping Quan. (2022) Synthesis and self-assembly of amphiphilic diblock polycarbonates with various pendant hydrophilic groups. POLYMER, 244 (124664). [PMID:] [10.1016/j.polymer.2022.124664]
6. Zhilang Xu, Lun Yuan, Qisong Liu, Defu Li, Changdao Mu, Lei Zhao, Xinying Li, Liming Ge. (2022) Crosslinking effect of dialdehyde cholesterol modified starch nanoparticles on collagen hydrogel. CARBOHYDRATE POLYMERS, 285 (119237). [PMID:35287860] [10.1016/j.carbpol.2022.119237]
7. Yanzhi Wang, Cancan Sun, Leaf Huang, Mengqian Liu, Lu Li, Xiping Wang, Linchao Wang, Shanshan Sun, Haiwei Xu, Gege Ma, Lei Zhang, Jiaxin Zheng, Hongmin Liu. (2022) Magnolol-loaded cholesteryl biguanide conjugate hydrochloride nanoparticles for triple-negative breast cancer therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 615 (121509). [PMID:35085734] [10.1016/j.ijpharm.2022.121509]
8. Yuqi Shen, Yue Shen, Jiaolun Li, Feng Ding, Yifeng Wang. (2021) Polyethyleneimine-anchored liposomes as scavengers for improving the efficiency of protein-bound uremic toxin clearance during dialysis. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 110 (4): (976-983). [PMID:34908219] [10.1002/jbm.a.37346]
9. Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu, Liming Ge. (2022) pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy. CARBOHYDRATE POLYMERS, 277 (118827). [PMID:34893244] [10.1016/j.carbpol.2021.118827]
10. Huan-Huan Ding, Jia-Zhu Chigan, Jian-Bin Zhen, Lu Liu, Yin-Sui Xu, Cheng Chen, Ke-Wu Yang. (2021) Cholesteroled polymer (Chol-b-Lys)-based nanoparticles (CL-NPs) confer antibacterial efficacy without resistance. NEW JOURNAL OF CHEMISTRY, 45 (44): (20743-20750). [PMID:] [10.1039/D1NJ03944J]
11. Liying Wang, Zimo Liu, Quan Zhou, Sufang Gu, Xiangsheng Liu, Jianxiang Huang, Haiping Jiang, Huifang Wang, Liping Cao, Jihong Sun, Youqing Shen, Huan Meng, Xiangrui Liu. (2021) Prodrug nanoparticles rationally integrating stroma modification and chemotherapy to treat metastatic pancreatic cancer. BIOMATERIALS, 278 (121176). [PMID:34656882] [10.1016/j.biomaterials.2021.121176]
12. Wu Xia, Li Xinying, Yang Like, Yuan Lun, Xu Zhilang, Xu Jinfang, Ge Liming, Mu Changdao, Li Defu. (2021) Stability Enhanced Pickering Emulsions Based on Gelatin and Dialdehyde Starch Nanoparticles as Simple Strategy for Structuring Liquid Oils. Food and Bioprocess Technology, 14 (8): (1600-1610). [PMID:] [10.1007/s11947-021-02661-8]
13. Ziqian Wang, Chenyue Zhan, Fang Zeng, Shuizhu Wu. (2020) A biopolymer-based and inflammation-responsive nanodrug for rheumatoid arthritis treatment via inhibiting JAK-STAT and JNK signalling pathways. Nanoscale, 12 (45): (23013-23027). [PMID:33191426] [10.1039/D0NR05551D]
14. Yongbin Xu, Yaxin Zi, Jinfeng Lei, Xingyue Mo, Zilun Shao, Yuyao Wu, Ye Tian, Defu Li, Changdao Mu. (2020) pH-Responsive nanoparticles based on cholesterol/imidazole modified oxidized-starch for targeted anticancer drug delivery. CARBOHYDRATE POLYMERS, 233 (115858). [PMID:32059909] [10.1016/j.carbpol.2020.115858]
15. Haifeng Sun, Dinglingge Cao, Yanhong Liu, Hui Wang, Xue Ke, Tianyuan Ci. (2018) Low molecular weight heparin-based reduction-sensitive nanoparticles for antitumor and anti-metastasis of orthotopic breast cancer. Biomaterials Science, 6 (8): (2172-2188). [PMID:29942949] [10.1039/C8BM00486B]
16. Haifeng Sun, Dinglingge Cao, Hao Wu, Huan Liu, Xue Ke, Tianyuan Ci. (2018) Development of low molecular weight heparin based nanoparticles for metastatic breast cancer therapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 112 (343). [PMID:29409771] [10.1016/j.ijbiomac.2018.01.195]
17. Bohong Guo, Danqiao Xu, Xiaohong Liu, Jun Yi. (2017) Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes. Drug Design Development and Therapy, [PMID:28684902] [10.2147/DDDT.S132841]
18. Xinhua Cao, Qianqian Ding, Aiping Gao, Haiting Lv, Na Zhao, Dan Liu. (2017) Regulation gel formation, hierarchical structures and surface wettability via isomeride effect in supramolecular organogel system. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 494 (170). [PMID:28157635] [10.1016/j.jcis.2017.01.080]
19. Wenhui Pan, Mengyao Qin, Guoguang Zhang, Yueming Long, Wenyi Ruan, Jingtong Pan, Zushuai Wu, Tao Wan, Chuanbin Wu, Yuehong Xu. (2016) Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery. International Journal of Nanomedicine, [PMID:27578973] [10.2147/IJN.S108545]
20. Bin Yang, Yin Lv, Jing-yi Zhu, Yun-tao Han, Hui-zhen Jia, Wei-hai Chen, Jun Feng, Xian-zheng Zhang, Ren-xi Zhuo. (2014) A pH-responsive drug nanovehicle constructed by reversible attachment of cholesterol to PEGylated poly(l-lysine) via catechol–boronic acid ester formation. Acta Biomaterialia, 10 (3686). [PMID:24879311] [10.1016/j.actbio.2014.05.018]
21. Yangling Li, Chang Liu, Ying Tan, Kun Xu, Cuige Lu, Pixin Wang. (2014) In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction. CARBOHYDRATE POLYMERS, 110 (87). [PMID:24906732] [10.1016/j.carbpol.2014.03.058]
22. Zhang Yu, Xiao ChunSheng, Li MingQiang, Ding JianXun, Yang ChenGuang, Zhuang XiuLi, Chen XueSi. (2014) Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy. Science China-Chemistry, 57 (4): (624-632). [PMID:] [10.1007/s11426-014-5078-y]
23. Yuejin Tong, Haidong Li, Huaimin Guan, Jianming Zhao, Saadat Majeed, Saima Anjum, Feng Liang, Guobao Xu. (2013) Electrochemical cholesterol sensor based on carbon nanotube@molecularly imprinted polymer modified ceramic carbon electrode. BIOSENSORS & BIOELECTRONICS, 47 (553). [PMID:23644061] [10.1016/j.bios.2013.03.072]

References

1. Wang Yanzhi, Wang Linchao, Chang Hanyue, Shen Qing, Zhang Sai, Sun Shanshan, Liu Ying, Zheng Jiaxin, Liu Hongmin. (2023) Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence. Drug Delivery and Translational Research, (16): (1-14). [PMID:37755673] [10.1007/s13346-023-01433-5]
2. Yina Zhang, Liying Wang, Jiajia Shao, Yanning Liu, Yining Lu, Jing Yang, Siduo Xu, Jingkang Zhang, Minwei Li, Xiangrui Liu, Min Zheng. (2023) Nano-calcipotriol as a potent anti-hepatic fibrosis agent. MedComm, 4 (5): (e354). [PMID:37638336] [10.1002/mco2.354]
3. Danrong Hu, Omar Mezghrani, Lei Zhang, Yi Chen, Xue Ke, Tianyuan Ci. (2023) GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy. International Journal of Nanomedicine, [PMID:27785019] [10.2147/IJN.S113469]
4. Wenzhu Yin, Bihua Deng, Zeyu Xu, Haiyan Wang, Fang Ma, Mingxu Zhou, Yu Lu, Jinqiu Zhang. (2023) Formulation and Evaluation of Lipidized Imiquimod as an Effective Adjuvant. ACS Infectious Diseases, 9 (2): (378–387). [PMID:36688646] [10.1021/acsinfecdis.2c00583]
5. Hong Zhai, Kaibin Chen, Yue Meng, Zejia Wu, Rongli Deng, Ying Bai, Jing Zhou, Daping Quan. (2022) Synthesis and self-assembly of amphiphilic diblock polycarbonates with various pendant hydrophilic groups. POLYMER, 244 (124664). [PMID:] [10.1016/j.polymer.2022.124664]
6. Zhilang Xu, Lun Yuan, Qisong Liu, Defu Li, Changdao Mu, Lei Zhao, Xinying Li, Liming Ge. (2022) Crosslinking effect of dialdehyde cholesterol modified starch nanoparticles on collagen hydrogel. CARBOHYDRATE POLYMERS, 285 (119237). [PMID:35287860] [10.1016/j.carbpol.2022.119237]
7. Yanzhi Wang, Cancan Sun, Leaf Huang, Mengqian Liu, Lu Li, Xiping Wang, Linchao Wang, Shanshan Sun, Haiwei Xu, Gege Ma, Lei Zhang, Jiaxin Zheng, Hongmin Liu. (2022) Magnolol-loaded cholesteryl biguanide conjugate hydrochloride nanoparticles for triple-negative breast cancer therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 615 (121509). [PMID:35085734] [10.1016/j.ijpharm.2022.121509]
8. Yuqi Shen, Yue Shen, Jiaolun Li, Feng Ding, Yifeng Wang. (2021) Polyethyleneimine-anchored liposomes as scavengers for improving the efficiency of protein-bound uremic toxin clearance during dialysis. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 110 (4): (976-983). [PMID:34908219] [10.1002/jbm.a.37346]
9. Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu, Liming Ge. (2022) pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy. CARBOHYDRATE POLYMERS, 277 (118827). [PMID:34893244] [10.1016/j.carbpol.2021.118827]
10. Huan-Huan Ding, Jia-Zhu Chigan, Jian-Bin Zhen, Lu Liu, Yin-Sui Xu, Cheng Chen, Ke-Wu Yang. (2021) Cholesteroled polymer (Chol-b-Lys)-based nanoparticles (CL-NPs) confer antibacterial efficacy without resistance. NEW JOURNAL OF CHEMISTRY, 45 (44): (20743-20750). [PMID:] [10.1039/D1NJ03944J]
11. Liying Wang, Zimo Liu, Quan Zhou, Sufang Gu, Xiangsheng Liu, Jianxiang Huang, Haiping Jiang, Huifang Wang, Liping Cao, Jihong Sun, Youqing Shen, Huan Meng, Xiangrui Liu. (2021) Prodrug nanoparticles rationally integrating stroma modification and chemotherapy to treat metastatic pancreatic cancer. BIOMATERIALS, 278 (121176). [PMID:34656882] [10.1016/j.biomaterials.2021.121176]
12. Wu Xia, Li Xinying, Yang Like, Yuan Lun, Xu Zhilang, Xu Jinfang, Ge Liming, Mu Changdao, Li Defu. (2021) Stability Enhanced Pickering Emulsions Based on Gelatin and Dialdehyde Starch Nanoparticles as Simple Strategy for Structuring Liquid Oils. Food and Bioprocess Technology, 14 (8): (1600-1610). [PMID:] [10.1007/s11947-021-02661-8]
13. Ziqian Wang, Chenyue Zhan, Fang Zeng, Shuizhu Wu. (2020) A biopolymer-based and inflammation-responsive nanodrug for rheumatoid arthritis treatment via inhibiting JAK-STAT and JNK signalling pathways. Nanoscale, 12 (45): (23013-23027). [PMID:33191426] [10.1039/D0NR05551D]
14. Yongbin Xu, Yaxin Zi, Jinfeng Lei, Xingyue Mo, Zilun Shao, Yuyao Wu, Ye Tian, Defu Li, Changdao Mu. (2020) pH-Responsive nanoparticles based on cholesterol/imidazole modified oxidized-starch for targeted anticancer drug delivery. CARBOHYDRATE POLYMERS, 233 (115858). [PMID:32059909] [10.1016/j.carbpol.2020.115858]
15. Haifeng Sun, Dinglingge Cao, Yanhong Liu, Hui Wang, Xue Ke, Tianyuan Ci. (2018) Low molecular weight heparin-based reduction-sensitive nanoparticles for antitumor and anti-metastasis of orthotopic breast cancer. Biomaterials Science, 6 (8): (2172-2188). [PMID:29942949] [10.1039/C8BM00486B]
16. Haifeng Sun, Dinglingge Cao, Hao Wu, Huan Liu, Xue Ke, Tianyuan Ci. (2018) Development of low molecular weight heparin based nanoparticles for metastatic breast cancer therapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 112 (343). [PMID:29409771] [10.1016/j.ijbiomac.2018.01.195]
17. Bohong Guo, Danqiao Xu, Xiaohong Liu, Jun Yi. (2017) Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes. Drug Design Development and Therapy, [PMID:28684902] [10.2147/DDDT.S132841]
18. Xinhua Cao, Qianqian Ding, Aiping Gao, Haiting Lv, Na Zhao, Dan Liu. (2017) Regulation gel formation, hierarchical structures and surface wettability via isomeride effect in supramolecular organogel system. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 494 (170). [PMID:28157635] [10.1016/j.jcis.2017.01.080]
19. Wenhui Pan, Mengyao Qin, Guoguang Zhang, Yueming Long, Wenyi Ruan, Jingtong Pan, Zushuai Wu, Tao Wan, Chuanbin Wu, Yuehong Xu. (2016) Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery. International Journal of Nanomedicine, [PMID:27578973] [10.2147/IJN.S108545]
20. Bin Yang, Yin Lv, Jing-yi Zhu, Yun-tao Han, Hui-zhen Jia, Wei-hai Chen, Jun Feng, Xian-zheng Zhang, Ren-xi Zhuo. (2014) A pH-responsive drug nanovehicle constructed by reversible attachment of cholesterol to PEGylated poly(l-lysine) via catechol–boronic acid ester formation. Acta Biomaterialia, 10 (3686). [PMID:24879311] [10.1016/j.actbio.2014.05.018]
21. Yangling Li, Chang Liu, Ying Tan, Kun Xu, Cuige Lu, Pixin Wang. (2014) In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction. CARBOHYDRATE POLYMERS, 110 (87). [PMID:24906732] [10.1016/j.carbpol.2014.03.058]
22. Zhang Yu, Xiao ChunSheng, Li MingQiang, Ding JianXun, Yang ChenGuang, Zhuang XiuLi, Chen XueSi. (2014) Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy. Science China-Chemistry, 57 (4): (624-632). [PMID:] [10.1007/s11426-014-5078-y]
23. Yuejin Tong, Haidong Li, Huaimin Guan, Jianming Zhao, Saadat Majeed, Saima Anjum, Feng Liang, Guobao Xu. (2013) Electrochemical cholesterol sensor based on carbon nanotube@molecularly imprinted polymer modified ceramic carbon electrode. BIOSENSORS & BIOELECTRONICS, 47 (553). [PMID:23644061] [10.1016/j.bios.2013.03.072]

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