Chonglou Saponin VII|68124-04-9|Paris saponin VII|Pennogenin tetraglycoside|Dioscinin|Paris VII|Paris saponin-VII|DTXSID101318576|HY-N3584|s9156|AKOS032946455|CCG-270613|BS-14117|CS-0023885|beta-D-Glucopyranoside, (3beta,25R)-17-hydroxyspirost-5-en-3-yl O
Specifications & Purity
98%
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Chonglou Saponin VII, a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
I2103109