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Cinacalcet - 98%, high purity , CAS No.226256-56-0, Allosteric modulator of CaS receptor;Allosteric modulator of mGlu 5 receptor
Basic Description Synonyms Cinacalcet|226256-56-0|AMG 073|AMG073|AMG-073|(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine|KRN1493|UNII-UAZ6V7728S|Cinacalcet (USAN)|UAZ6V7728S|CHEBI:48390|HSDB 7318|KRN-1493|N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluorom Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of CaS receptor;Allosteric modulator of mGlu 5 receptor
Names and Identifiers IUPAC Name N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine INCHI InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1 InChi Key VDHAWDNDOKGFTD-MRXNPFEDSA-N Canonical SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F Isomeric SMILES C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F PubChem CID 156419 Molecular Weight 357.41
Chemical and Physical Properties Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H302: Harmful if swallowed
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
References 1. Nemeth EF, Heaton WH, Miller M, Fox J, Balandrin MF, Van Wagenen BC, Colloton M, Karbon W, Scherrer J, Shatzen E et al. . (2004) Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl.. J Pharmacol Exp Ther, 308 (2): (627-35). [PMID:14593085 ] 2. Levi R, Ben-Dov IZ, Lavi-Moshayoff V, Dinur M, Martin D, Naveh-Many T, Silver J. (2006) Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1.. J Am Soc Nephrol, 17 (1): (107-12). [PMID:16291838 ]
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