cis-Diammineplatinum dichloride - 99.5% , high purity , CAS No.15663-27-1

Item Number
C295225
Grouped product items
SKUSizeAvailabilityPrice Qty
C295225-250mg
250mg
In stock
$147.90
C295225-1g
1g
In stock
$411.90
C295225-5g
5g
In stock
$1,435.90

Basic Description

Specifications & PurityMoligand™, ≥99.5%
Biochemical and Physiological MechanismsForms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G 2 /M phase. Antitumor, cros
Storage TempProtected from light,Room temperature,Argon charged
Shipped InNormal
GradeMoligand™
Product Description

Product class
hAPIs, Metal based hAPIs


Chemical properties

Chemical formula

H6N2Cl2Pt

Empirical formula

[Pt(NH3)2Cl2]

Molecular weight

300.05

Metal

Pt

Theoretical metal content

65.02

Physical state

crystalline

Color
Metal purity

yellow

99.95

Names and Identifiers

INCHI 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChi Key LXZZYRPGZAFOLE-UHFFFAOYSA-L
Canonical SMILES N.N.Cl[Pt]Cl
WGK Germany 3
RTECS TP2450000
UN Number 2928
Packing Group I
Molecular Weight 300.1

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

23 results found

Lot NumberCertificate TypeDateItem
L2407027Certificate of AnalysisNov 18, 2024 C295225
L2407015Certificate of AnalysisNov 18, 2024 C295225
K2429525Certificate of AnalysisNov 18, 2024 C295225
K2314537Certificate of AnalysisOct 21, 2023 C295225
K2314543Certificate of AnalysisOct 21, 2023 C295225
K2314541Certificate of AnalysisOct 21, 2023 C295225
K2314540Certificate of AnalysisOct 21, 2023 C295225
K2314539Certificate of AnalysisOct 21, 2023 C295225
K2314538Certificate of AnalysisOct 21, 2023 C295225
J2418286Certificate of AnalysisOct 21, 2023 C295225
H2412488Certificate of AnalysisOct 21, 2023 C295225
J2316047Certificate of AnalysisNov 03, 2022 C295225
J2309072Certificate of AnalysisNov 03, 2022 C295225
H2315307Certificate of AnalysisNov 03, 2022 C295225
F2314496Certificate of AnalysisNov 03, 2022 C295225
D2323932Certificate of AnalysisNov 03, 2022 C295225
L2201739Certificate of AnalysisNov 03, 2022 C295225
L2201791Certificate of AnalysisNov 03, 2022 C295225
L2202051Certificate of AnalysisNov 03, 2022 C295225
C2221080Certificate of AnalysisMar 31, 2022 C295225
A2214408Certificate of AnalysisJan 03, 2022 C295225
A2214410Certificate of AnalysisJan 03, 2022 C295225
A2214409Certificate of AnalysisJan 03, 2022 C295225

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Chemical and Physical Properties

SolubilitySoluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml)
SensitivityMoisture sensitive & Light sensitive
Melt Point(°C)270°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H319:Causes serious eye irritation

H300:Fatal if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H340:May cause genetic defects

H350:May cause cancer

H370:Causes damage to organs

H316:Causes mild skin irritation

H362:May cause harm to breast-fed children

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P201:Obtain special instructions before use.

P337+P313:IF eye irritation persists: Get medical advice/attention.

P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

P308+P311:IF exposed or concerned: Call a POISON CENTER/doctor/...

P202:Do not handle until all safety precautions have been read and understood.

P330:Rinse mouth.

WGK Germany 3
RTECS TP2450000
Class 6.1, 8
Merck Index 2317
RIDADR UN 3288 6.1 / PGII

Related Documents

Citations of This Product

1. Jiang Hao, Tian Hailong, Wang Zhihan, Li Bowen, Chen Rui, Luo Kangjia, Lu Shuaijun, Nice Edouard C., Zhang Wei, Huang Canhua, Zhou Yuping, Zheng Shaojiang, Gao Feng.  (2023)  Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment.  Biomaterials Research,  27  (1): (1-20).  [PMID:37742011] [10.1186/s40824-023-00427-1]
2. Leyi Fang, Xiao-Tong Pan, Kang Liu, Dechen Jiang, Deju Ye, Li-Na Ji, Kang Wang, Xing-Hua Xia.  (2023)  Surface-Roughened SERS-Active Single Silver Nanowire for Simultaneous Detection of Intracellular and Extracellular pHs.  ACS Applied Materials & Interfaces,  15  (17): (20677–20685).  [PMID:37071781] [10.1021/acsami.3c00844]
3. Yunfan Liu, Jiazhou Zhai, Fei Qin, Liping Gao, Yongxin She, Mengqiang Wang.  (2023)  Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:] [10.3136/fstr.FSTR-D-21-00284]
4. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2023)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,  23  (45).  [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]
5. Zhou Yafu, Yan Jianhua, Chen Huiguo, Zhou Wenwu, Yang Jinsong.  (2022)  MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.  CELLS TISSUES ORGANS,    (1-12).  [PMID:36273455] [10.1159/000527684]
6. Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng, Yong-gui Wu.  (2022)  A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis.  INTERNATIONAL IMMUNOPHARMACOLOGY,  108  (108849).  [PMID:35588657] [10.1016/j.intimp.2022.108849]
7. Yaodong Yi, Liping Li, Feifeng Song, Ping Li, Mingyang Chen, Shixin Ni, Hengbin Zhang, Hui Zhou, Su Zeng, Huidi Jiang.  (2021)  L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity.  TOXICOLOGY,  459  (152853).  [PMID:34252480] [10.1016/j.tox.2021.152853]
8. Liuwei Zhang, Ming Qian, Hongyan Cui, Shuang Zeng, Jingyun Wang, Qixian Chen.  (2021)  Spatiotemporal Concurrent Liberation of Cytotoxins from Dual-Prodrug Nanomedicine for Synergistic Antitumor Therapy.  ACS Applied Materials & Interfaces,  13  (5): (6053–6068).  [PMID:33525873] [10.1021/acsami.0c21422]
9. Zheng Di-Wei, Pan Pei, Chen Ke-Wei, Fan Jin-Xuan, Li Chu-Xin, Cheng Han, Zhang Xian-Zheng.  (2020)  An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure.  Nature Biomedical Engineering,  (9): (853-862).  [PMID:32632226] [10.1038/s41551-020-0582-1]
10. Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang.  (2020)  L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy.  BIOCHEMICAL PHARMACOLOGY,  177  (114021).  [PMID:32389634] [10.1016/j.bcp.2020.114021]
11. Peng-Chao Zhang, Xiao Liu, Man-Mei Li, Yan-Yan Ma, Hong-Tao Sun, Xu-Yan Tian, Yan Wang, Min Liu, Liang-Shun Fu, Yi-Fei Wang, Hong-Yuan Chen, Zhong Liu.  (2020)  AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo.  BIOCHEMICAL PHARMACOLOGY,  172  (113771).  [PMID:31863779] [10.1016/j.bcp.2019.113771]
12. Chen Xiao, Hang Hu, Hai Yang, Si Li, Hui Zhou, Jian Ruan, Yuting Zhu, Xiangliang Yang, Zifu Li.  (2019)  Colloidal hydroxyethyl starch for tumor-targeted platinum delivery.  Nanoscale Advances,  (3): (1002-1012).  [PMID:36133197] [10.1039/C8NA00271A]
13. Guangjian Zeng, Meiying Liu, Ruming Jiang, Chunning Heng, Qiang Huang, Liucheng Mao, Junfeng Hui, Fengjie Deng, Xiaoyong Zhang, Yen Wei.  (2017)  Surface grafting of Eu3 + doped luminescent hydroxyapatite nanomaterials through metal free light initiated atom transfer radical polymerization for theranostic applications.  Materials Science & Engineering C-Materials for Biological Applications,  77  (420).  [PMID:28532048] [10.1016/j.msec.2017.03.261]
14. Xiangxiang Liu, Bowei Liu, Sijia Gao, Zhaocheng Wang, Ye Tian, Man Wu, Shidong Jiang, Zhongwei Niu.  (2017)  Glyco-decorated tobacco mosaic virus as a vector for cisplatin delivery.  Journal of Materials Chemistry B,  (11): (2078-2085).  [PMID:32263681] [10.1039/C7TB00100B]
15. Huang Wuren, Zhang Jie, Yang Bing, Beerntsen Brenda T., Song Hongsheng, Ling Erjun.  (2016)  DNA duplication is essential for the repair of gastrointestinal perforation in the insect midgut.  Scientific Reports,  (1): (1-10).  [PMID:26754166] [10.1038/srep19142]

References

1. Jiang Hao, Tian Hailong, Wang Zhihan, Li Bowen, Chen Rui, Luo Kangjia, Lu Shuaijun, Nice Edouard C., Zhang Wei, Huang Canhua, Zhou Yuping, Zheng Shaojiang, Gao Feng.  (2023)  Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment.  Biomaterials Research,  27  (1): (1-20).  [PMID:37742011] [10.1186/s40824-023-00427-1]
2. Leyi Fang, Xiao-Tong Pan, Kang Liu, Dechen Jiang, Deju Ye, Li-Na Ji, Kang Wang, Xing-Hua Xia.  (2023)  Surface-Roughened SERS-Active Single Silver Nanowire for Simultaneous Detection of Intracellular and Extracellular pHs.  ACS Applied Materials & Interfaces,  15  (17): (20677–20685).  [PMID:37071781] [10.1021/acsami.3c00844]
3. Yunfan Liu, Jiazhou Zhai, Fei Qin, Liping Gao, Yongxin She, Mengqiang Wang.  (2023)  Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:] [10.3136/fstr.FSTR-D-21-00284]
4. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2023)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,  23  (45).  [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]
5. Zhou Yafu, Yan Jianhua, Chen Huiguo, Zhou Wenwu, Yang Jinsong.  (2022)  MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.  CELLS TISSUES ORGANS,    (1-12).  [PMID:36273455] [10.1159/000527684]
6. Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng, Yong-gui Wu.  (2022)  A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis.  INTERNATIONAL IMMUNOPHARMACOLOGY,  108  (108849).  [PMID:35588657] [10.1016/j.intimp.2022.108849]
7. Yaodong Yi, Liping Li, Feifeng Song, Ping Li, Mingyang Chen, Shixin Ni, Hengbin Zhang, Hui Zhou, Su Zeng, Huidi Jiang.  (2021)  L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity.  TOXICOLOGY,  459  (152853).  [PMID:34252480] [10.1016/j.tox.2021.152853]
8. Liuwei Zhang, Ming Qian, Hongyan Cui, Shuang Zeng, Jingyun Wang, Qixian Chen.  (2021)  Spatiotemporal Concurrent Liberation of Cytotoxins from Dual-Prodrug Nanomedicine for Synergistic Antitumor Therapy.  ACS Applied Materials & Interfaces,  13  (5): (6053–6068).  [PMID:33525873] [10.1021/acsami.0c21422]
9. Zheng Di-Wei, Pan Pei, Chen Ke-Wei, Fan Jin-Xuan, Li Chu-Xin, Cheng Han, Zhang Xian-Zheng.  (2020)  An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure.  Nature Biomedical Engineering,  (9): (853-862).  [PMID:32632226] [10.1038/s41551-020-0582-1]
10. Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang.  (2020)  L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy.  BIOCHEMICAL PHARMACOLOGY,  177  (114021).  [PMID:32389634] [10.1016/j.bcp.2020.114021]
11. Peng-Chao Zhang, Xiao Liu, Man-Mei Li, Yan-Yan Ma, Hong-Tao Sun, Xu-Yan Tian, Yan Wang, Min Liu, Liang-Shun Fu, Yi-Fei Wang, Hong-Yuan Chen, Zhong Liu.  (2020)  AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo.  BIOCHEMICAL PHARMACOLOGY,  172  (113771).  [PMID:31863779] [10.1016/j.bcp.2019.113771]
12. Chen Xiao, Hang Hu, Hai Yang, Si Li, Hui Zhou, Jian Ruan, Yuting Zhu, Xiangliang Yang, Zifu Li.  (2019)  Colloidal hydroxyethyl starch for tumor-targeted platinum delivery.  Nanoscale Advances,  (3): (1002-1012).  [PMID:36133197] [10.1039/C8NA00271A]
13. Guangjian Zeng, Meiying Liu, Ruming Jiang, Chunning Heng, Qiang Huang, Liucheng Mao, Junfeng Hui, Fengjie Deng, Xiaoyong Zhang, Yen Wei.  (2017)  Surface grafting of Eu3 + doped luminescent hydroxyapatite nanomaterials through metal free light initiated atom transfer radical polymerization for theranostic applications.  Materials Science & Engineering C-Materials for Biological Applications,  77  (420).  [PMID:28532048] [10.1016/j.msec.2017.03.261]
14. Xiangxiang Liu, Bowei Liu, Sijia Gao, Zhaocheng Wang, Ye Tian, Man Wu, Shidong Jiang, Zhongwei Niu.  (2017)  Glyco-decorated tobacco mosaic virus as a vector for cisplatin delivery.  Journal of Materials Chemistry B,  (11): (2078-2085).  [PMID:32263681] [10.1039/C7TB00100B]
15. Huang Wuren, Zhang Jie, Yang Bing, Beerntsen Brenda T., Song Hongsheng, Ling Erjun.  (2016)  DNA duplication is essential for the repair of gastrointestinal perforation in the insect midgut.  Scientific Reports,  (1): (1-10).  [PMID:26754166] [10.1038/srep19142]

Solution Calculators