Basic Description

Synonyms	Cisplatin
Specifications & Purity	Moligand™, Pt,65%
Biochemical and Physiological Mechanisms	Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G 2 /M phase. Antitumor, cros
Storage Temp	Protected from light,Argon charged
Shipped In	Normal
Grade	Moligand™
Note	Unstable; make up solutions fresh and use immediately. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product class hAPIs, Metal based hAPIs Chemical properties Chemical formula H6N2Cl2Pt Empirical formula [Pt(NH3)2Cl2] Molecular weight 300.05 Metal Pt Theoretical metal content 65.02 Physical state crystalline Color yellow

Names and Identifiers

INCHI	1S/2ClH.2H3N.Pt/h21H;21H3;/q;;;;+2/p-2
InChi Key	LXZZYRPGZAFOLE-UHFFFAOYSA-L
Canonical SMILES	N.N.Cl[Pt]Cl
WGK Germany	3
RTECS	TP2450000
UN Number	2928
Packing Group	I
Molecular Weight	300.1

Database links

DrugBank Ligand	DB00515
CAS Registry No.	15663-27-1
ChEBI	CHEBI:27899
Wikipedia	Cisplatin
PubChem CID	441203
ChEMBL Ligand	CHEMBL11359

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot Number	Certificate Type	Date	Item
G2412026	Certificate of Analysis	Jul 25, 2024	D109812
K2413293	Certificate of Analysis	Jul 23, 2024	D109812
G2416107	Certificate of Analysis	Jun 14, 2024	D109812
G2416073	Certificate of Analysis	Jun 14, 2024	D109812
C2415143	Certificate of Analysis	Mar 21, 2024	D109812
L2107580	Certificate of Analysis	Sep 20, 2023	D109812
L2107495	Certificate of Analysis	Sep 20, 2023	D109812
L2305010	Certificate of Analysis	Nov 14, 2022	D109812
I2322118	Certificate of Analysis	Nov 14, 2022	D109812
D2306134	Certificate of Analysis	Nov 14, 2022	D109812
D2306133	Certificate of Analysis	Nov 14, 2022	D109812
C2420027	Certificate of Analysis	Nov 14, 2022	D109812
G2308207	Certificate of Analysis	Jun 01, 2022	D109812
F2215374	Certificate of Analysis	Jun 01, 2022	D109812
F2215373	Certificate of Analysis	Jun 01, 2022	D109812
F2215372	Certificate of Analysis	Jun 01, 2022	D109812
C2405078	Certificate of Analysis	Jun 01, 2022	D109812
E2421021	Certificate of Analysis	Nov 11, 2021	D109812

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Chemical and Physical Properties

Solubility	Soluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml)
Sensitivity	Moisture sensitive & Light sensitive
Melt Point(°C)	270°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H300:Fatal if swallowed H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H350:May cause cancer H370:Causes damage to organs H316:Causes mild skin irritation H362:May cause harm to breast-fed children
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P201:Obtain special instructions before use. P337+P313:IF eye irritation persists: Get medical advice/attention. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P308+P311:IF exposed or concerned: Call a POISON CENTER/doctor/... P202:Do not handle until all safety precautions have been read and understood. P330:Rinse mouth.
WGK Germany	3
RTECS	TP2450000
Class	6.1, 8
Merck Index	2317
RIDADR	UN 3288 6.1 / PGII

FAQs and Articles

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiang Hao, Tian Hailong, Wang Zhihan, Li Bowen, Chen Rui, Luo Kangjia, Lu Shuaijun, Nice Edouard C., Zhang Wei, Huang Canhua, Zhou Yuping, Zheng Shaojiang, Gao Feng. (2023) Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment. Biomaterials Research, 27 (1): (1-20). [PMID:37742011] [10.1186/s40824-023-00427-1]
2. Leyi Fang, Xiao-Tong Pan, Kang Liu, Dechen Jiang, Deju Ye, Li-Na Ji, Kang Wang, Xing-Hua Xia. (2023) Surface-Roughened SERS-Active Single Silver Nanowire for Simultaneous Detection of Intracellular and Extracellular pHs. ACS Applied Materials & Interfaces, 15 (17): (20677–20685). [PMID:37071781] [10.1021/acsami.3c00844]
3. Yunfan Liu, Jiazhou Zhai, Fei Qin, Liping Gao, Yongxin She, Mengqiang Wang. (2023) Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats. FOOD SCIENCE AND TECHNOLOGY RESEARCH, [PMID:] [10.3136/fstr.FSTR-D-21-00284]
4. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]
5. Zhou Yafu, Yan Jianhua, Chen Huiguo, Zhou Wenwu, Yang Jinsong. (2022) MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4. CELLS TISSUES ORGANS, (1-12). [PMID:36273455] [10.1159/000527684]
6. Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng, Yong-gui Wu. (2022) A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis. INTERNATIONAL IMMUNOPHARMACOLOGY, 108 (108849). [PMID:35588657] [10.1016/j.intimp.2022.108849]
7. Yaodong Yi, Liping Li, Feifeng Song, Ping Li, Mingyang Chen, Shixin Ni, Hengbin Zhang, Hui Zhou, Su Zeng, Huidi Jiang. (2021) L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. TOXICOLOGY, 459 (152853). [PMID:34252480] [10.1016/j.tox.2021.152853]
8. Liuwei Zhang, Ming Qian, Hongyan Cui, Shuang Zeng, Jingyun Wang, Qixian Chen. (2021) Spatiotemporal Concurrent Liberation of Cytotoxins from Dual-Prodrug Nanomedicine for Synergistic Antitumor Therapy. ACS Applied Materials & Interfaces, 13 (5): (6053–6068). [PMID:33525873] [10.1021/acsami.0c21422]
9. Zheng Di-Wei, Pan Pei, Chen Ke-Wei, Fan Jin-Xuan, Li Chu-Xin, Cheng Han, Zhang Xian-Zheng. (2020) An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. Nature Biomedical Engineering, 4 (9): (853-862). [PMID:32632226] [10.1038/s41551-020-0582-1]
10. Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang. (2020) L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy. BIOCHEMICAL PHARMACOLOGY, 177 (114021). [PMID:32389634] [10.1016/j.bcp.2020.114021]
11. Peng-Chao Zhang, Xiao Liu, Man-Mei Li, Yan-Yan Ma, Hong-Tao Sun, Xu-Yan Tian, Yan Wang, Min Liu, Liang-Shun Fu, Yi-Fei Wang, Hong-Yuan Chen, Zhong Liu. (2020) AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo. BIOCHEMICAL PHARMACOLOGY, 172 (113771). [PMID:31863779] [10.1016/j.bcp.2019.113771]
12. Chen Xiao, Hang Hu, Hai Yang, Si Li, Hui Zhou, Jian Ruan, Yuting Zhu, Xiangliang Yang, Zifu Li. (2019) Colloidal hydroxyethyl starch for tumor-targeted platinum delivery. Nanoscale Advances, 1 (3): (1002-1012). [PMID:36133197] [10.1039/C8NA00271A]
13. Guangjian Zeng, Meiying Liu, Ruming Jiang, Chunning Heng, Qiang Huang, Liucheng Mao, Junfeng Hui, Fengjie Deng, Xiaoyong Zhang, Yen Wei. (2017) Surface grafting of Eu3 + doped luminescent hydroxyapatite nanomaterials through metal free light initiated atom transfer radical polymerization for theranostic applications. Materials Science & Engineering C-Materials for Biological Applications, 77 (420). [PMID:28532048] [10.1016/j.msec.2017.03.261]
14. Xiangxiang Liu, Bowei Liu, Sijia Gao, Zhaocheng Wang, Ye Tian, Man Wu, Shidong Jiang, Zhongwei Niu. (2017) Glyco-decorated tobacco mosaic virus as a vector for cisplatin delivery. Journal of Materials Chemistry B, 5 (11): (2078-2085). [PMID:32263681] [10.1039/C7TB00100B]
15. Huang Wuren, Zhang Jie, Yang Bing, Beerntsen Brenda T., Song Hongsheng, Ling Erjun. (2016) DNA duplication is essential for the repair of gastrointestinal perforation in the insect midgut. Scientific Reports, 6 (1): (1-10). [PMID:26754166] [10.1038/srep19142]

References

1. Luo R et al.. (2019) Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment.. Clin Cancer Res, 25 (23): (7243-7255). [PMID:31506388]
2. Tröndle K et al.. (2022) Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids.. Int J Bioprint, 8 (2): (528). [PMID:35702333]
3. Tan Z et al.. (2019) Environmental stresses induce karyotypic instability in colorectal cancer cells.. Mol Biol Cell, 30 (42-55). [PMID:30379607]
4. Carter RJ et al.. (2019) Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.. Cell Death Dis, 10 (12): (912). [PMID:31801952]
5. Qin W et al.. (2016) Inhibiting microRNA-449 Attenuates Cisplatin-Induced Injury in NRK-52E Cells Possibly via Regulating the SIRT1/P53/BAX Pathway.. Med Sci Monit, 22 (818-23). [PMID:26968221]
6. Black JC et al.. (2016) Regulation of Transient Site-specific Copy Gain by MicroRNA.. J Biol Chem, 291 (10): (4862-71). [PMID:26755726]
7. Mahmood N et al.. (2020) S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis.. J Cell Mol Med, 24 (18): (10322-10337). [PMID:32720467]
8. Jiang Hao, Tian Hailong, Wang Zhihan, Li Bowen, Chen Rui, Luo Kangjia, Lu Shuaijun, Nice Edouard C., Zhang Wei, Huang Canhua, Zhou Yuping, Zheng Shaojiang, Gao Feng. (2023) Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment. Biomaterials Research, 27 (1): (1-20). [PMID:37742011] [10.1186/s40824-023-00427-1]
9. Leyi Fang, Xiao-Tong Pan, Kang Liu, Dechen Jiang, Deju Ye, Li-Na Ji, Kang Wang, Xing-Hua Xia. (2023) Surface-Roughened SERS-Active Single Silver Nanowire for Simultaneous Detection of Intracellular and Extracellular pHs. ACS Applied Materials & Interfaces, 15 (17): (20677–20685). [PMID:37071781] [10.1021/acsami.3c00844]
10. Yunfan Liu, Jiazhou Zhai, Fei Qin, Liping Gao, Yongxin She, Mengqiang Wang. (2023) Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats. FOOD SCIENCE AND TECHNOLOGY RESEARCH, [PMID:] [10.3136/fstr.FSTR-D-21-00284]
11. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2023) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, 23 (45). [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]
12. Zhou Yafu, Yan Jianhua, Chen Huiguo, Zhou Wenwu, Yang Jinsong. (2022) MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4. CELLS TISSUES ORGANS, (1-12). [PMID:36273455] [10.1159/000527684]
13. Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng, Yong-gui Wu. (2022) A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis. INTERNATIONAL IMMUNOPHARMACOLOGY, 108 (108849). [PMID:35588657] [10.1016/j.intimp.2022.108849]
14. Yaodong Yi, Liping Li, Feifeng Song, Ping Li, Mingyang Chen, Shixin Ni, Hengbin Zhang, Hui Zhou, Su Zeng, Huidi Jiang. (2021) L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. TOXICOLOGY, 459 (152853). [PMID:34252480] [10.1016/j.tox.2021.152853]
15. Liuwei Zhang, Ming Qian, Hongyan Cui, Shuang Zeng, Jingyun Wang, Qixian Chen. (2021) Spatiotemporal Concurrent Liberation of Cytotoxins from Dual-Prodrug Nanomedicine for Synergistic Antitumor Therapy. ACS Applied Materials & Interfaces, 13 (5): (6053–6068). [PMID:33525873] [10.1021/acsami.0c21422]
16. Zheng Di-Wei, Pan Pei, Chen Ke-Wei, Fan Jin-Xuan, Li Chu-Xin, Cheng Han, Zhang Xian-Zheng. (2020) An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. Nature Biomedical Engineering, 4 (9): (853-862). [PMID:32632226] [10.1038/s41551-020-0582-1]
17. Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang. (2020) L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy. BIOCHEMICAL PHARMACOLOGY, 177 (114021). [PMID:32389634] [10.1016/j.bcp.2020.114021]
18. Peng-Chao Zhang, Xiao Liu, Man-Mei Li, Yan-Yan Ma, Hong-Tao Sun, Xu-Yan Tian, Yan Wang, Min Liu, Liang-Shun Fu, Yi-Fei Wang, Hong-Yuan Chen, Zhong Liu. (2020) AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo. BIOCHEMICAL PHARMACOLOGY, 172 (113771). [PMID:31863779] [10.1016/j.bcp.2019.113771]
19. Chen Xiao, Hang Hu, Hai Yang, Si Li, Hui Zhou, Jian Ruan, Yuting Zhu, Xiangliang Yang, Zifu Li. (2019) Colloidal hydroxyethyl starch for tumor-targeted platinum delivery. Nanoscale Advances, 1 (3): (1002-1012). [PMID:36133197] [10.1039/C8NA00271A]
20. Guangjian Zeng, Meiying Liu, Ruming Jiang, Chunning Heng, Qiang Huang, Liucheng Mao, Junfeng Hui, Fengjie Deng, Xiaoyong Zhang, Yen Wei. (2017) Surface grafting of Eu3 + doped luminescent hydroxyapatite nanomaterials through metal free light initiated atom transfer radical polymerization for theranostic applications. Materials Science & Engineering C-Materials for Biological Applications, 77 (420). [PMID:28532048] [10.1016/j.msec.2017.03.261]
21. Xiangxiang Liu, Bowei Liu, Sijia Gao, Zhaocheng Wang, Ye Tian, Man Wu, Shidong Jiang, Zhongwei Niu. (2017) Glyco-decorated tobacco mosaic virus as a vector for cisplatin delivery. Journal of Materials Chemistry B, 5 (11): (2078-2085). [PMID:32263681] [10.1039/C7TB00100B]
22. Huang Wuren, Zhang Jie, Yang Bing, Beerntsen Brenda T., Song Hongsheng, Ling Erjun. (2016) DNA duplication is essential for the repair of gastrointestinal perforation in the insect midgut. Scientific Reports, 6 (1): (1-10). [PMID:26754166] [10.1038/srep19142]

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SKU	Size	Availability	Price
D109812-100mg	100mg	In stock	$33.90
D109812-250mg	250mg	In stock	$64.90
D109812-1g	1g	In stock	$198.90
D109812-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$893.90

cis-Diammineplatinum dichloride - Pt,65%, high purity , CAS No.15663-27-1