cis-Diammineplatinum dichloride - Pt,65%, high purity , CAS No.15663-27-1

6 Citations
Item Number
D109812
Grouped product items
SKUSizeAvailabilityPrice Qty
D109812-100mg
100mg
In stock
$33.90
D109812-250mg
250mg
In stock
$64.90
D109812-1g
1g
In stock
$198.90
D109812-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$893.90

Potent, broad spectrum antineoplastic agent

Basic Description

SynonymsCisplatin
Specifications & PurityPt,65%
Storage TempProtected from light,Argon charged
Shipped InNormal
GradeMoligand™
Product Description

Product class
hAPIs, Metal based hAPIs


Chemical properties

Chemical formula

H6N2Cl2Pt

Empirical formula

[Pt(NH3)2Cl2]

Molecular weight

300.05

Metal

Pt

Theoretical metal content

65.02

Physical state

crystalline

Color

yellow

Names and Identifiers

INCHI 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChi Key LXZZYRPGZAFOLE-UHFFFAOYSA-L
Canonical SMILES N.N.Cl[Pt]Cl
WGK Germany 3
RTECS TP2450000
UN Number 2928
Packing Group I
Molecular Weight 300.1

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot NumberCertificate TypeDateItem
G2412026Certificate of AnalysisJul 25, 2024 D109812
G2416107Certificate of AnalysisJun 14, 2024 D109812
G2416073Certificate of AnalysisJun 14, 2024 D109812
F2215372Certificate of AnalysisMar 21, 2024 D109812
F2215373Certificate of AnalysisMar 21, 2024 D109812
F2215374Certificate of AnalysisMar 21, 2024 D109812
L2107580Certificate of AnalysisSep 20, 2023 D109812
L2107495Certificate of AnalysisSep 20, 2023 D109812
L2305010Certificate of AnalysisNov 14, 2022 D109812
I2322118Certificate of AnalysisNov 14, 2022 D109812
D2306134Certificate of AnalysisNov 14, 2022 D109812
D2306133Certificate of AnalysisNov 14, 2022 D109812
C2420027Certificate of AnalysisNov 14, 2022 D109812
G2308207Certificate of AnalysisJun 01, 2022 D109812
C2405078Certificate of AnalysisJun 01, 2022 D109812
E2421021Certificate of AnalysisNov 11, 2021 D109812
C2415143Certificate of AnalysisNov 11, 2021 D109812

Show more⌵

Chemical and Physical Properties

SolubilitySoluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml)
SensitivityMoisture sensitive & Light sensitive
Melt Point(°C)270°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H319:Causes serious eye irritation

H300:Fatal if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H340:May cause genetic defects

H350:May cause cancer

H370:Causes damage to organs

H316:Causes mild skin irritation

H362:May cause harm to breast-fed children

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P201:Obtain special instructions before use.

P337+P313:IF eye irritation persists: Get medical advice/attention.

P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

P308+P311:IF exposed or concerned: Call a POISON CENTER/doctor/...

P202:Do not handle until all safety precautions have been read and understood.

P330:Rinse mouth.

WGK Germany 3
RTECS TP2450000
Class 6.1, 8
Merck Index 2317
RIDADR UN 3288 6.1 / PGII

Related Documents

Citations of This Product

1. Jiang Hao, Tian Hailong, Wang Zhihan, Li Bowen, Chen Rui, Luo Kangjia, Lu Shuaijun, Nice Edouard C., Zhang Wei, Huang Canhua, Zhou Yuping, Zheng Shaojiang, Gao Feng.  (2023)  Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment.  Biomaterials Research,  27  (1): (1-20).  [PMID:37742011]
2. Leyi Fang, Xiao-Tong Pan, Kang Liu, Dechen Jiang, Deju Ye, Li-Na Ji, Kang Wang, Xing-Hua Xia.  (2023)  Surface-Roughened SERS-Active Single Silver Nanowire for Simultaneous Detection of Intracellular and Extracellular pHs.  ACS Applied Materials & Interfaces,  15  (17): (20677–20685).  [PMID:37071781]
3. Yunfan Liu, Jiazhou Zhai, Fei Qin, Liping Gao, Yongxin She, Mengqiang Wang.  (2023)  Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:]
4. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2023)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,  23  (45).  [PMID:36406255]
5. Zhou Yafu, Yan Jianhua, Chen Huiguo, Zhou Wenwu, Yang Jinsong.  (2022)  MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.  CELLS TISSUES ORGANS,    (1-12).  [PMID:36273455]
6. Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng, Yong-gui Wu.  (2022)  A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis.  INTERNATIONAL IMMUNOPHARMACOLOGY,  108  (108849).  [PMID:35588657]

References

1. Luo R et al..  (2019)  Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment..  Clin Cancer Res,  25  (23): (7243-7255).  [PMID:31506388]
2. Tröndle K et al..  (2022)  Deep Learning-Assisted Nephrotoxicity Testing with Bioprinted Renal Spheroids..  Int J Bioprint,  (2): (528).  [PMID:35702333]
3. Carter RJ et al..  (2019)  Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck..  Cell Death Dis,  10  (12): (912).  [PMID:31801952]
4. Tan Z et al..  (2019)  Environmental stresses induce karyotypic instability in colorectal cancer cells..  Mol Biol Cell,  30  (42-55).  [PMID:30379607]
5. Qin W et al..  (2016)  Inhibiting microRNA-449 Attenuates Cisplatin-Induced Injury in NRK-52E Cells Possibly via Regulating the SIRT1/P53/BAX Pathway..  Med Sci Monit,  22  (818-23).  [PMID:26968221]
6. Black JC et al..  (2016)  Regulation of Transient Site-specific Copy Gain by MicroRNA..  J Biol Chem,  291  (10): (4862-71).  [PMID:26755726]
7. Mahmood N et al..  (2020)  S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis..  J Cell Mol Med,  24  (18): (10322-10337).  [PMID:32720467]
8. Jiang Hao, Tian Hailong, Wang Zhihan, Li Bowen, Chen Rui, Luo Kangjia, Lu Shuaijun, Nice Edouard C., Zhang Wei, Huang Canhua, Zhou Yuping, Zheng Shaojiang, Gao Feng.  (2023)  Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment.  Biomaterials Research,  27  (1): (1-20).  [PMID:37742011]
9. Leyi Fang, Xiao-Tong Pan, Kang Liu, Dechen Jiang, Deju Ye, Li-Na Ji, Kang Wang, Xing-Hua Xia.  (2023)  Surface-Roughened SERS-Active Single Silver Nanowire for Simultaneous Detection of Intracellular and Extracellular pHs.  ACS Applied Materials & Interfaces,  15  (17): (20677–20685).  [PMID:37071781]
10. Yunfan Liu, Jiazhou Zhai, Fei Qin, Liping Gao, Yongxin She, Mengqiang Wang.  (2023)  Protective role of polyphenol extract from highland barley against cisplatin-induced renal toxicity and mitochondrial damage in rats.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:]
11. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2023)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,  23  (45).  [PMID:36406255]
12. Zhou Yafu, Yan Jianhua, Chen Huiguo, Zhou Wenwu, Yang Jinsong.  (2022)  MicroRNA-133a-3p Inhibits Lung Adenocarcinoma Development and Cisplatin Resistance through Targeting GINS4.  CELLS TISSUES ORGANS,    (1-12).  [PMID:36273455]
13. Xue-qi Liu, Ming-ming Liu, Ling Jiang, Li Gao, Yao Zhang, Yue-bo Huang, Xian Wang, Wei Zhu, Han-xu Zeng, Xiao-ming Meng, Yong-gui Wu.  (2022)  A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis.  INTERNATIONAL IMMUNOPHARMACOLOGY,  108  (108849).  [PMID:35588657]

Solution Calculators