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CJ13610 - ≥95%, high purity , CAS No.179420-17-8, Inhibitor of 5-LOX

Moligand™
≥95%

CAS#: 179420-17-8
Formula: C₂₂H₂₃N₃O₂S
Molecular Weight: 393.50
PubChem CID: 9821945

Item Number

C608577

Grouped product items
SKU	Size	Availability	Price
C608577-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$38.90
C608577-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608577-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$223.90
C608577-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90
C608577-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$767.90
C608577-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,229.90

View related series

5-LOX Inhibitor Lipoxygenase Metabolic Enzyme/Protease

Basic Description

Synonyms	179420-17-8\|CJ-13610\|CJ-13,610\|CJ 13610\|4-(3-((4-(2-Methyl-1H-imidazol-1-yl)phenyl)sulfanyl)phenyl)tetrahydro-2H-pyran-4-carboxamide\|CHEMBL195309\|5275PJ1C59\|CJ13610\|2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]
Specifications & Purity	Moligand™, ≥95%
Biochemical and Physiological Mechanisms	CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM). CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tet
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of 5-LOX
Product Description	CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages. Application： CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 2 Activities

Discover Target: ALOX5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

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Names and Identifiers

IUPAC Name	4-[3-[4-(2-methylimidazol-1-yl)phenyl]sulfanylphenyl]oxane-4-carboxamide
INCHI	InChI=1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
InChi Key	VPTONMHDLLMOOV-UHFFFAOYSA-N
Canonical SMILES	CC1=NC=CN1C2=CC=C(C=C2)SC3=CC=CC(=C3)C4(CCOCC4)C(=O)N
Isomeric SMILES	CC1=NC=CN1C2=CC=C(C=C2)SC3=CC=CC(=C3)C4(CCOCC4)C(=O)N
WGK Germany	3
Alternate CAS	179420-27-0
PubChem CID	9821945
Molecular Weight	393.50

CAS Registry No.

179420-17-8

PubChem CID

9821945

ChEMBL Ligand

CHEMBL195309

WGK Germany

RIDADR

NONHforallmodesoftransport

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