Clazakizumab (anti-IL-6) - Primary antibody, specific to IL6, >95% (SDS-PAGE&SEC), high purity, Human IgG1, INHIBITOR of Interleukin-6 inhibitor

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Cynomolgus monkey,Human,Mouse
Isotype: Human IgG1

Application:

Item Number

Ab175494

Grouped product items
SKU	Size	Availability	Price
Ab175494-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90
Ab175494-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$519.90
Ab175494-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,399.90
Ab175494-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series

Basic Description

Product Name	Clazakizumab (anti-IL-6) - Primary antibody, specific to IL6, >95% (SDS-PAGE&SEC), high purity, Human IgG1
Synonyms	ALD-518;ALD518;BMS-945429
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Biochemical and Physiological Mechanisms	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It indu
Specificity	IL6
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	INHIBITOR of Interleukin-6 inhibitor
Product Description	Clazakizumab (anti-IL-6) is a monoclonal antibody with high affinity and specificity for the IL-6 (interleukin-6) cytokine. Clazakizumab (anti-IL-6) may be helpful in inhibiting the cytokine response to SARS-CoV-2 in COVID-19. Clazakizumab (anti-IL-6) can be used for the research of psoriatic arthritis (PsA) and renal antibody-mediated rejection.

Product Properties

Isotype	Human IgG1
Light Chain Type	kappa
SDS-PAGE	145.24 kDa
Purification Method	Protein A purified
Purity	>95% (SDS-PAGE&SEC)
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1236278-28-6

IMGT/mAb-DB

Wikipedia

References

1. Bayliss TJ, Smith JT, Schuster M, Dragnev KH, Rigas JR. (2011) A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer.. Expert Opin Biol Ther, 11 (12): (1663-8). [PMID:21995322]
2. Mease PJ, Gottlieb AB, Berman A, Drescher E, Xing J, Wong R, Banerjee S. (2016) The Efficacy and Safety of Clazakizumab, an Anti-Interleukin-6 Monoclonal Antibody, in a Phase IIb Study of Adults With Active Psoriatic Arthritis.. Arthritis Rheumatol, 68 (9): (2163-73). [PMID:27059799]
3. Ma JD, Heavey SF, Revta C, Roeland EJ. (2014) Novel investigational biologics for the treatment of cancer cachexia.. Expert Opin Biol Ther, 14 (8): (1113-20). [PMID:24707881]
4. FitzGerald O. (2016) Spondyloarthropathies: IL-6 blockade in psoriatic arthritis - a new therapeutic option?. Nat Rev Rheumatol, 12 (6): (318-9). [PMID:27215204]
5. Weinblatt ME, Mease P, Mysler E, Takeuchi T, Drescher E, Berman A, Xing J, Zilberstein M, Banerjee S, Emery P. (2015) The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, dose-ranging study.. Arthritis Rheumatol, 67 (10): (2591-600). [PMID:26138593]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description