Clemizole - ≥98%, high purity , CAS No.442-52-4, Channel blocker of TRPC3;Channel blocker of TRPC4;Channel blocker of TRPC5;Channel blocker of TRPC6

Item Number

C125175

Grouped product items
SKU	Size	Availability	Price
C125175-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$91.90
C125175-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$184.90
C125175-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$663.90

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Basic Description

Synonyms	Clemizole\|442-52-4\|Histacur\|Clemizol\|Histakool\|Clemizolum\|Lergopenin\|1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole\|Depocural\|1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole\|1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenz
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Description: IC50 Value: 8mM (NS4B) [1] Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replicat
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPC3;Channel blocker of TRPC4;Channel blocker of TRPC5;Channel blocker of TRPC6
Note	25mg、100mg卖完停产，不再备货
Product Description	Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

Names and Identifiers

IUPAC Name	1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole
INCHI	InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2
InChi Key	CJXAEXPPLWQRFR-UHFFFAOYSA-N
Canonical SMILES	C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl
Isomeric SMILES	C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl
Alternate CAS	442-52-4
PubChem CID	2782
NSC Number	46261
MeSH Entry Terms	clemizole
Molecular Weight	325.84

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
H2429127	Certificate of Analysis	Sep 04, 2024	C125175
L2220134	Certificate of Analysis	Jan 07, 2023	C125175
H1605038	Certificate of Analysis	Apr 14, 2022	C125175
J2325028	Certificate of Analysis	Apr 14, 2022	C125175

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Basic Description