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CM 4620 - 99%, high purity , CAS No.1713240-67-5, Channel blocker of Orai1;Channel blocker of Orai2

Moligand™
≥99%

CAS#: 1713240-67-5
Formula: C₁₉H₁₁ClF₃N₃O₃
Molecular Weight: 421.76
PubChem CID: 122507647

Item Number

C413652

Grouped product items
SKU	Size	Availability	Price
C413652-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$325.90
C413652-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$543.90
C413652-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$924.90
C413652-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,665.90
C413652-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$529.90

Calcium Channel Inhibitors

View related series

Orai1 Channel blocker Orai2 Channel blocker

Basic Description

Synonyms	BS-15636 \| CM 4620 \| C73294 \| BDBM50575336 \| SCHEMBL18038390 \| CS-0022201 \| 564AW1RR37 \| SB18686 \| AC-35758 \| CM4620 \| CM-4620 \| N-[5-(6-Chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2-pyrazinyl]-2-fluoro-6-methylbenzamide \| HY-101942 \| N-[5-(6-chloro-2,2-dif
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	CM 4620 is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of Orai1;Channel blocker of Orai2
Product Description	Information CM 4620 CM 4620 is an inhibitor of calcium-release activated calcium-channel (CRAC channel) . CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively. Targets Orai1/STIM1-mediated Ca2+ currents (Cell-free assay); Orai2/STIM1-mediated currents (Cell-free assay) 120 nM; 900 nM

Associated Targets

ORAI1 Tchem Calcium release-activated calcium channel protein 1 1 Activities

Discover Target: ORAI1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STIM1 Tbio Stromal interaction molecule 1 0 Activities

Discover Target: STIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ORAI2 Tchem Protein orai-2 1 Activities

Discover Target: ORAI2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
INCHI	InChI=1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27)
InChi Key	QQMKTHUGOQDEIL-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
Isomeric SMILES	CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
Alternate CAS	1713240-67-5
PubChem CID	122507647
MeSH Entry Terms	Auxora;CM 4620;CM-128;CM-4620;CM128;CM4620;N-(5-(6-chloro-2,2-difluorobenzo(d)(1,3)dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide;zegocractin
Molecular Weight	421.76

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10 results found

Lot Number	Certificate Type	Date	Item
C2425193	Certificate of Analysis	Feb 19, 2024	C413652
C2425194	Certificate of Analysis	Feb 19, 2024	C413652
C2425195	Certificate of Analysis	Feb 19, 2024	C413652
C2425196	Certificate of Analysis	Feb 19, 2024	C413652
C2425197	Certificate of Analysis	Feb 19, 2024	C413652
C2425198	Certificate of Analysis	Feb 19, 2024	C413652
C2425199	Certificate of Analysis	Feb 19, 2024	C413652
C2425200	Certificate of Analysis	Feb 19, 2024	C413652
C2425204	Certificate of Analysis	Feb 19, 2024	C413652
C2425205	Certificate of Analysis	Feb 19, 2024	C413652

References

1. Gerasimenko JV, Gryshchenko O, Ferdek PE, Stapleton E, Hébert TO, Bychkova S, Peng S, Begg M, Gerasimenko OV, Petersen OH. (2013) Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy.. Proc Natl Acad Sci USA, 110 (32): (13186-91). [PMID:23878235]
2. Gukovskaya AS, Pandol SJ, Gukovsky I. (2016) New insights into the pathways initiating and driving pancreatitis.. Curr Opin Gastroenterol, 32 (5): (429-435). [PMID:27428704]

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