CM-579 trihydrochloride - 98%, high purity , CAS No.C659211

Item Number

C659211

Grouped product items
SKU	Size	Availability	Price
C659211-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
C659211-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$390.90
C659211-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90
C659211-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,500.90

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Basic Description

Specifications & Purity	98%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Product Description	CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT , with IC 50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. Appearance:Solid IC50& Target:DNA Methyltransferase 32 nM (IC 50 ) DNMT1 1.5 nM (Kd) DNMT3A 92 nM (IC 50 ) DNMT3B 1000 nM (IC 50 ) G9a 16 nM (IC 50 ) In Vitro:The K d of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC 50 s of 92 nM and 1000 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT , with IC 50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

Canonical SMILES

CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl

Molecular Weight

602.04

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Basic Description