| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C655920-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $330.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases -selective inhibitor, with IC 50 values of 114 nM and 673 nM for PDE5 and HDAC1 , respectively. CM-675 has potential to treat Alzheimer’s disease. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases -selective inhibitor, with IC 50 values of 114 nM and 673 nM for PDE5 and HDAC1 , respectively. CM-675 has potential to treat Alzheimer’s disease In Vitro CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:HDAC1 673 nM (IC 50 , 30 min (time-dependent)) PDE5 114 nM nM (IC 50 ) |
| Canonical SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C |
|---|---|
| Molecular Weight | 536.62 |
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