CMPD-1 - ≥99%(HPLC), high purity , CAS No.41179-33-3, Inhibitor of MAPK activated protein kinase 2

Item Number

C286549

• Synonyms: CMPD1|41179-33-3|MK2a Inhibitor|CMPD-1|4-(2'-Fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide|4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide|2'-FLUORO-N-(4-HYDROXYPHENYL)-[1,1'-BIPHENYL]-4-BUTANAMIDE|CHEMBL235658|MAPKAPK2a Inhibitor|
• Specifications & Purity: Moligand™, ≥99%(HPLC)
• Biochemical and Physiological Mechanisms: Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki= 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic i
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of MAPK activated protein kinase 2

Product Description

Product description

A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.

A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.