Basic Description

Synonyms	Coa disulfide \| 5NG \| CoA-disulfide \| [[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-
Specifications & Purity	≥85%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Description Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. CoA is a thiol compound subject to oxidation. Oxidized CoA may be used to study reduction systems (CoA disulfide reductase (CoADR) systems) that regenerate reduced CoA in vivo. Furthermore, oxidized CoA may be used to study unique functions of this molecule in vivo.

Names and Identifiers

IUPAC Name	[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-4-[[3-[2-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl] hydrogen phosphate
INCHI	InChI=1S/C42H70N14O32P6S2/c1-41(2,15-81-93(75,76)87-91(71,72)79-13-21-29(85-89(65,66)67)27(59)39(83-21)55-19-53-25-33(43)49-17-51-35(25)55)31(61)37(63)47-7-5-23(57)45-9-11-95-96-12-10-46-24(58)6-8-48-38(64)32(62)42(3,4)16-82-94(77,78)88-92(73,74)80-14-22-30(86-90(68,69)70)28(60)40(84-22)56-20-54-26-34(44)50-18-52-36(26)56/h17-22,27-32,39-40,59-62H,5-16H2,1-4H3,(H,45,57)(H,46,58)(H,47,63)(H,48,64)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H2,43,49,51)(H2,44,50,52)(H2,65,66,67)(H2,68,69,70)/t21-,22-,27-,28-,29-,30-,31+,32+,39-,40-/m1/s1
InChi Key	YAISMNQCMHVVLO-ODFVJXNFSA-N
Canonical SMILES	CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)OP(=O)(O)O)O)O
Isomeric SMILES	CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C(N=CN=C65)N)O)OP(=O)(O)O)O)O
PubChem CID	169341
Molecular Weight	1533.1

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Flash Point(°F)	Not applicable
Flash Point(°C)	Not applicable

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H315:Causes skin irritation H318:Causes serious eye damage
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
RIDADR	NONH for all modes of transport

References

1. Gasmi L, McLennan AG. (2001) The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives.. Biochem J, 357 (Pt 1): (33-8). [PMID:11415433] [10.1021/op500134e]
2. H F Gilbert,M D Stewart. (1981-02-25) Inactivation of hydroxymethylglutaryl-CoA reductase from yeast by coenzyme A disulfide.. The Journal of biological chemistry, 256 ((4)): (1782-1785). [PMID:7007371]
3. S B delCardayre,K P Stock,G L Newton,R C Fahey,J E Davies. (1998-04-16) Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.. The Journal of biological chemistry, 273 ((10)): (5744-5751). [PMID:9488707]
4. S B delCardayre,J E Davies. (1998-04-16) Staphylococcus aureus coenzyme A disulfide reductase, a new subfamily of pyridine nucleotide-disulfide oxidoreductase. Sequence, expression, and analysis of cdr.. The Journal of biological chemistry, 273 ((10)): (5752-5757). [PMID:9488708]
5. J Luba,V Charrier,A Claiborne. (1999-03-03) Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.. Biochemistry, 38 ((9)): (2725-2737). [PMID:10052943]
6. Dennis R Harris,Donald E Ward,Jeremy M Feasel,Kyle M Lancaster,Ryan D Murphy,T Conn Mallet,Edward J Crane. (2005-02-22) Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles.. The FEBS journal, 272 ((5)): (1189-1200). [PMID:15720393]
7. T Conn Mallett,Jamie R Wallen,P Andrew Karplus,Hiroaki Sakai,Tomitake Tsukihara,Al Claiborne. (2006-09-20) Structure of coenzyme A-disulfide reductase from Staphylococcus aureus at 1.54 A resolution.. Biochemistry, 45 ((38)): (11278-11289). [PMID:16981688]
8. Rob Ofman,Dave Speijer,René Leen,Ronald J A Wanders. (2005-09-28) Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity.. The Biochemical journal, 393 ((Pt 2)): (537-543). [PMID:16185196]
9. Farhad Forouhar,In-Sun Lee,Jelena Vujcic,Slavoljub Vujcic,Jianwei Shen,Sergey M Vorobiev,Rong Xiao,Thomas B Acton,Gaetano T Montelione,Carl W Porter,Liang Tong. (2005-10-08) Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase.. The Journal of biological chemistry, 280 ((48)): (40328-40336). [PMID:16210326]
10. Charles S Hummel,Kyle M Lancaster,Edward J Crane. (2005-10-11) Determination of coenzyme A levels in Pyrococcus furiosus and other Archaea: implications for a general role for coenzyme A in thermophiles.. FEMS microbiology letters, 252 ((2)): (229-234). [PMID:16213671]
11. Julie A Boylan,Charles S Hummel,Stéphane Benoit,Jorge Garcia-Lara,Jennifer Treglown-Downey,Edward J Crane,Frank C Gherardini. (2006-01-05) Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response.. Molecular microbiology, 59 ((2)): (475-486). [PMID:16390443]
12. Kevin D Revell,Bart Heldreth,Timothy E Long,Seyoung Jang,Edward Turos. (2007-01-30) N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus.. Bioorganic & medicinal chemistry, 15 ((6)): (2453-2467). [PMID:17258460]
13. Jamie R Wallen,Carleitta Paige,T Conn Mallett,P Andrew Karplus,Al Claiborne. (2008-04-11) Pyridine nucleotide complexes with Bacillus anthracis coenzyme A-disulfide reductase: a structural analysis of dual NAD(P)H specificity.. Biochemistry, 47 ((18)): (5182-5193). [PMID:18399646]

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Coenzyme A, oxidized lithium salt - ≥85%, high purity , CAS No.31664-36-5

Basic Description

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price	Qty
C463091-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$366.90
C463091-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$882.90