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Colistin sodium methanesulfonate - ~11,500U/mg, high purity , CAS No.8068-28-8

  • ~11,500U/mg
Item Number
C485907
Grouped product items
SKUSizeAvailabilityPrice Qty
C485907-10MU
10MU
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$537.90
C485907-100MU
100MU
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,334.90
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Basic Description

Specifications & Purity~11,500U/mg
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

Description

Chemical structure: peptideColistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments ofP. aeruginosainfections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients .

Names and Identifiers

INCHI 1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-
InChi Key WSDSONZFNWDYGZ-BKFDUBCBSA-I
Canonical SMILES [Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C
Molecular Weight 1759.9

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility H2O: 50mg/mL
Flash Point(°F)Not applicable
Flash Point(°C)Not applicable

Safety and Hazards(GHS)

RIDADR NONH for all modes of transport

Related Documents

 SDS

 Specification Sheet

References

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4. Sonia Luque,Santiago Grau,Nuria Berenguer,Juan Pablo Horcajada,Luisa Sorlí,María Milagro Montero,Esther Salas.  (2011-03-29)  [Shedding light on the use of colistin: still gaps to be filled]..  Enfermedades infecciosas y microbiologia clinica,  29  ((4)): (287-296).  [PMID:21440335]
5. W Couet,N Grégoire,P Gobin,P J Saulnier,D Frasca,S Marchand,O Mimoz.  (2011-05-06)  Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers..  Clinical pharmacology and therapeutics,  89  ((6)): (875-879).  [PMID:21544080]
6. Phillip J Bergen,Jian Li,Roger L Nation.  (2011-08-13)  Dosing of colistin-back to basic PK/PD..  Current opinion in pharmacology,  11  ((5)): (464-469).  [PMID:21835694]
7. Hung-Jen Tang,Yin-Ching Chuang,Wen-Chien Ko,Chi-Chung Chen,Jiunn-Min Shieh,Chung-Hua Chen,Nan-Yao Lee,Shyh-Ren Chiang.  (2011-11-18)  Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia..  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,  16  ((1)): (e34-e40).  [PMID:22088863]
8. C Bozkurt-Guzel,A A Gerceker.  (2012-03-01)  In vitro pharmacodynamic properties of colistin methanesulfonate and amikacin against Pseudomonas aeruginosa..  Indian journal of medical microbiology,  30  ((1)): (34-38).  [PMID:22361758]
9. Lidia Dalfino,Filomena Puntillo,Adriana Mosca,Rosa Monno,Maria Luigia Spada,Sara Coppolecchia,Giuseppe Miragliotta,Francesco Bruno,Nicola Brienza.  (2012-03-17)  High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study..  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,  54  ((12)): (1720-1726).  [PMID:22423120]
10. Jason A Roberts,Jeffrey Lipman.  (2012-03-17)  Editorial commentary: Closing the loop--a colistin clinical study to confirm dosing recommendations from PK/PD modeling..  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,  54  ((12)): (1727-1729).  [PMID:22423122]
11. Stephanie J Wallace,Jian Li,Roger L Nation,Richard J Prankerd,Ben J Boyd.  (2012-05-25)  Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation..  Journal of pharmaceutical sciences,  101  ((9)): (3347-3359).  [PMID:22623044]
12. Roberto Imberti,Maria Cusato,Giovanni Accetta,Valeria Marinò,Francesco Procaccio,Alfredo Del Gaudio,Giorgio A Iotti,Mario Regazzi.  (2012-06-13)  Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration of colistin methanesulfonate..  Antimicrobial agents and chemotherapy,  56  ((8)): (4416-4421).  [PMID:22687507]
13. Kavi J Littlewood,Kyoko Higashi,Jeroen P Jansen,Gorana Capkun-Niggli,Maria-Magdalena Balp,Gerd Doering,Harm A W M Tiddens,Gerhild Angyalosi.  (2012-06-22)  A network meta-analysis of the efficacy of inhaled antibiotics for chronic Pseudomonas infections in cystic fibrosis..  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,  11  ((5)): (419-426).  [PMID:22717535]
14. Stacy Sommerfeld Ross,Jennifer Fiegel.  (2012-06-26)  Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms..  International journal of antimicrobial agents,  40  ((2)): (177-181).  [PMID:22727773]
15. Zoe E Athanassa,Sophia L Markantonis,Marina-Zoe F Fousteri,Pavlos M Myrianthefs,Eleni G Boutzouka,Athanassios Tsakris,George J Baltopoulos.  (2012-07-20)  Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients..  Intensive care medicine,  38  ((11)): (1779-1786).  [PMID:22810779]
16. Paige Waterman,Melissa Barber,Amy C Weintrob,Regina VanBrakle,Robin Howard,Michael P Kozar,Romney Andersen,Glenn Wortmann.  (2012-07-28)  The elution of colistimethate sodium from polymethylmethacrylate and calcium phosphate cement beads..  American journal of orthopedics (Belle Mead, N.J.),  41  ((6)): (256-259).  [PMID:22837988]
17. Anne H de Boer,Paul Hagedoorn,Robert Woolhouse,Ed Wynn.  (2012-08-14)  Computational fluid dynamics (CFD) assisted performance evaluation of the Twincer™ disposable high-dose dry powder inhaler..  The Journal of pharmacy and pharmacology,  64  ((9)): (1316-1325).  [PMID:22881443]
18. A M Healan,W Gray,E J Fuchs,J M Griffiss,R A Salata,J Blumer.  (2012-10-17)  Stability of colistimethate sodium in aqueous solution..  Antimicrobial agents and chemotherapy,  56  ((12)): (6432-6433).  [PMID:23070159]
19. Matti Karvanen,Diamantis Plachouras,Lena E Friberg,Elisabeth Paramythiotou,Evangelos Papadomichelakis,Ilias Karaiskos,Iraklis Tsangaris,Apostolos Armaganidis,Otto Cars,Helen Giamarellou.  (2012-11-14)  Colistin methanesulfonate and colistin pharmacokinetics in critically ill patients receiving continuous venovenous hemodiafiltration..  Antimicrobial agents and chemotherapy,  57  ((1)): (668-671).  [PMID:23147733]
20. Mairi Ziaka,Sophia L Markantonis,Marizoza Fousteri,Paris Zygoulis,Dimitris Panidis,Marios Karvouniaris,Demosthenes Makris,Epaminondas Zakynthinos.  (2013-01-22)  Combined intravenous and intraventricular administration of colistin methanesulfonate in critically ill patients with central nervous system infection..  Antimicrobial agents and chemotherapy,  57  ((4)): (1938-1940).  [PMID:23335739]
21. Mohamed Al-Aloul,Dilip Nazareth,Martin Walshaw.  (2013-11-14)  Nebulized tobramycin in the treatment of adult CF pulmonary exacerbations..  Journal of aerosol medicine and pulmonary drug delivery,  27  ((4)): (299-305).  [PMID:24219814]
22. P Tappenden,S Harnan,L Uttley,M Mildred,C Carroll,A Cantrell.  (2013-12-03)  Colistimethate sodium powder and tobramycin powder for inhalation for the treatment of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis: systematic review and economic model..  Health technology assessment (Winchester, England),  17  ((56)): (v-xvii).  [PMID:24290164]
23. Thomas Mercier,Fréderic Tissot,Céline Gardiol,Natascia Corti,Stéphane Wehrli,Monia Guidi,Chantal Csajka,Thierry Buclin,William Couet,Oscar Marchetti,Laurent A Decosterd.  (2014-12-03)  High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate..  Journal of chromatography. A,  1369  (52-63).  [PMID:25441071]
24. David Collie,Laura Glendinning,John Govan,Steven Wright,Elisabeth Thornton,Peter Tennant,Catherine Doherty,Gerry McLachlan.  (2015-11-07)  Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium..  PloS one,  10  ((11)): (e0142097-e0142097).  [PMID:26544950]
25. Sachin Gupta,Deepak Govil,Prem N Kakar,Om Prakash,Deep Arora,Shibani Das,Pradeep Govil,Ashima Malhotra.  (2009-11-03)  Colistin and polymyxin B: a re-emergence..  Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine,  13  ((2)): (49-53).  [PMID:19881183]
26. S M Garonzik,J Li,V Thamlikitkul,D L Paterson,S Shoham,J Jacob,F P Silveira,A Forrest,R L Nation.  (2011-05-11)  Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients..  Antimicrobial agents and chemotherapy,  55  ((7)): (3284-3294).  [PMID:21555763]
27. Istemi Han Celik,Serife Suna Oguz,Gamze Demirel,Omer Erdeve,Ugur Dilmen.  (2011-08-03)  Outcome of ventilator-associated pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa treated with aerosolized colistin in neonates: a retrospective chart review..  European journal of pediatrics,  171  ((2)): (311-316).  [PMID:21809011]
28. Fernando Docobo-Pérez,Patrice Nordmann,Juan Domínguez-Herrera,Rafael López-Rojas,Younes Smani,Laurent Poirel,Jerónimo Pachón.  (2011-12-14)  Efficacies of colistin and tigecycline in mice with experimental pneumonia due to NDM-1-producing strains of Klebsiella pneumoniae and Escherichia coli..  International journal of antimicrobial agents,  39  ((3)): (251-254).  [PMID:22154856]
29. Nikolaos Markou,Marizoza Fousteri,Sophia L Markantonis,Basilios Zidianakis,Despina Hroni,Eleni Boutzouka,George Baltopoulos.  (2012-07-14)  Colistin pharmacokinetics in intensive care unit patients on continuous venovenous haemodiafiltration: an observational study..  The Journal of antimicrobial chemotherapy,  67  ((10)): (2459-2462).  [PMID:22790220]
30. Antje Schuster,Cynthia Haliburn,Gerd Döring,Martin Harris Goldman.  (2012-11-09)  Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study..  Thorax,  68  ((4)): (344-350).  [PMID:23135343]
31. Kasper Aanaes,Christian von Buchwald,Thomas Hjuler,Marianne Skov,Mikkel Alanin,Helle Krogh Johansen.  (2013-02-15)  The effect of sinus surgery with intensive follow-up on pathogenic sinus bacteria in patients with cystic fibrosis..  American journal of rhinology & allergy,  27  ((1)): (e1-e4).  [PMID:23406585]

Solution Calculators

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