sterile-filtered, high purity, purified by chromatography, Type VII-S,≥4 FALGPA units/mg solid,≥700 CDU/mg solid (CDU = collagen digestion units)
Biochemical and Physiological Mechanisms
Clostridium histolyticum contains two classes of collagenases. Clostridial collagenases are more effective than mammalian collagenases. It cleaves at multiple cleavage sites within the collagen triple helix. Clostridial collagenases are involved in bacter
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
sterile-filtered
Product Description
Collagenase from Clostridium histolyticum has been used:
to induce intracerebral hemorrhage (ICH) in mice
to digest collagen 3D gels for immunofluorescence
to cause focal blood extravasation and hemorrhage in mouse
Collagenase has been used in the preparation of arterial tissue for the study of Advanced Glycosylation End Products (AGE). The enzyme has also been used along with other proteases for the disaggregation of human tumor, mouse kidney, human brain, lung epithelium and many other tissues. It is also effective in liver and kidney perfusion studies, digestion of pancreas, and isolation of nonparenchymal hepatocytes.
