compound 5i , CAS No.C609335, Inhibitor of mitogen-activated protein kinase kinase kinase kinase 1;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 3

Item Number

C609335

Grouped product items
SKU	Size	Availability	Price	Qty
C609335-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C609335-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Synonyms

compound 5i

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of mitogen-activated protein kinase kinase kinase kinase 1;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 3

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C30H33N7O3/c1-30(2,39)19-37-17-22(15-33-37)25-16-32-29-34-23-11-10-21(14-31)20(13-23)7-5-6-12-40-27-9-4-3-8-24(27)26(18-38)35-28(25)36-29/h3-4,8-11,13,15-17,26,38-39H,5-7,12,18-19H2,1-2H3,(H2,32,34,35,36)/t26-/m1/s1
InChi Key	DSSNAGYVGTYAGH-AREMUKBSSA-N
Canonical SMILES	OC[C@H]1Nc2c(cnc(Nc3cc(CCCCOc4c1cccc4)c(cc3)C#N)n2)c1cn(CC(C)(O)C)nc1

References

1. Sawasdikosol S, Russo KM, Burakoff SJ. (2003) Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2-induced fos gene transcription.. Blood, 101 (9): (3687-9). [PMID:12522005]
2. Alzabin S, Pyarajan S, Yee H, Kiefer F, Suzuki A, Burakoff S, Sawasdikosol S. (2010) Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response.. Cancer Immunol Immunother, 59 (3): (419-29). [PMID:19787351]
3. Wu P, Sneeringer CJ, Pitts KE, Day ES, Chan BK, Wei B, Lehoux I, Mortara K, Li H, Wu J et al.. (2019) Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.. Structure, 27 (1): (125-133.e4). [PMID:30503777]
4. Wang MS, Wang ZZ, Li ZL, Gong Y, Duan CX, Cheng QH, Huang W, Yang GF. (2023) Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.. J Med Chem, 66 (1): (611-626). [PMID:36542759]

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