Compound E, gamma;-secretase inhibitor - ≥99%, high purity , CAS No.209986-17-4

Item Number

C275008

Grouped product items
SKU	Size	Availability	Price	Qty
C275008-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$157.90
C275008-250μg	250μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$47.90

Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor

Basic Description

Synonyms	E98743 \| BS-15830 \| N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide \| EX-A3838 \| CHEBI:131161 \| C27H24F2N4O3 \| GSI-XXI \| Compound E \| gamma-Secretase Inhibitor XXI \| H
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor (IC 50 = 0.3 nM). Active in vitro and in vivo .
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide
INCHI	InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
InChi Key	JNGZXGGOCLZBFB-IVCQMTBJSA-N
Canonical SMILES	CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
Isomeric SMILES	C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
PubChem CID	11306390
Molecular Weight	490.5

References

1. Naylor RW et al.. (2018) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion.. Elife, 7 [PMID:30394875]
2. Liu X et al.. (2018) BMP9 overexpressing adipose-derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathway.. Exp Ther Med, 16 (6): (4623-4631). [PMID:30542413]
3. Kang Y et al.. (2018) Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys.. Cell Rep, 25 (9): (2563-2576.e9). [PMID:30485820]
4. Zhang YF et al.. (2022) MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1.. Front Cell Neurosci, 16 (866020). [PMID:35685988]
5. Alhashem Z et al.. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration.. Elife, 11 [PMID:35438077]
6. Slaninova V et al.. (2016) Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle.. Open Biol, 6 (2): (150155). [PMID:26887408]

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Basic Description