| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C656794-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $605.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Argon charged,Store at -80°C |
| Shipped In | Dry ice |
| Product Description | Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1 . In Vitro Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC 50 95 nM vs. MS-275 EC 50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1) |
| Canonical SMILES | C1C(C1N)C2=CC=C(C=C2)NC(=O)CCCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N |
|---|---|
| Molecular Weight | 428.53 |
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