| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C650316-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $600.90 |
Alkaloids Indole Alkaloids
| Synonyms | CORONARIDINE|Methyl ibogamine-18-carboxylate|(-)-Coronaridine|467-77-6|Coronardine|CHEBI:3887|EINECS 207-398-7|NSC 127490|SCHEMBL2343450|DTXSID60963642|NVVDQMVGALBDGE-PZXGUROGSA-N|FS-8035|HY-121118|CS-0079497|methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapen |
|---|---|
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression. In Vitro Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC 50 values >40 μM. It agaisnt wnt-dependent cells with IC 50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively. Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged. In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC 30 value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner. At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude and rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 and hα2β2γ2). The PAM activity of Catharanthine's are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| IUPAC Name | methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate |
|---|---|
| INCHI | InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14+,19+,21-/m1/s1 |
| InChi Key | NVVDQMVGALBDGE-PZXGUROGSA-N |
| Canonical SMILES | CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC |
| Isomeric SMILES | CC[C@H]1C[C@@H]2C[C@@]3([C@H]1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC |
| Alternate CAS | 467-77-6,4503-12-2 (mono-hydrochloride) |
| PubChem CID | 6426909 |
| MeSH Entry Terms | coronardine;coronardine monohydrochloride;coronardine monohydrochloride, (+-)-isomer;coronaridine |
| Molecular Weight | 338.44 |
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