CORT-108297 - 97%, high purity , Glucocorticoid receptor antagonist, CAS No.1018679-79-2, Glucocorticoid receptor antagonist

Item Number

C171679

Grouped product items
SKU	Size	Availability	Price
C171679-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$274.90
C171679-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$622.90
C171679-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$907.90

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Basic Description

Synonyms	CORT-108297\|1018679-79-2\|Cort108297\|CORT 108297\|ADS-108297\|CHEMBL271220\|(R)-4A-(ethoxymethyl)-1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline\|A17W0640NB\|(R)-4a-(Ethoxymethyl)-1-(4-fluorophen
Specifications & Purity	97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	ANTAGONIST
Mechanism of action	Glucocorticoid receptor antagonist
Product Description	Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(4aR)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline
INCHI	InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1
InChi Key	SLKURXRZHJOZOD-RUZDIDTESA-N
Canonical SMILES	CCOC[C@]12CC3=C(C=C1CCN(C2)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F)N(N=C3)C5=CC=C(C=C5)F
Isomeric SMILES	CCOC[C@]12CC3=C(C=C1CCN(C2)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F)N(N=C3)C5=CC=C(C=C5)F
PubChem CID	44454750
Molecular Weight	535.55

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H302:Harmful if swallowed H320:Causes eye irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

Solution Calculators

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Basic Description