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Costundide - analytical standard,>98%, high purity , CAS No.553-21-9
Basic Description Synonyms Costunolide|553-21-9|(+)-costunolide|Costunlide|Costunolid|Costus lactone|CHEMBL86416|CHEBI:3900|(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one|(E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid Specifications & Purity analytical standard, ≥98% Biochemical and Physiological Mechanisms Description:
Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade analytical standard Note 卖完停产，不再备货 Product Description Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway
Names and Identifiers IUPAC Name (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one INCHI InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1 InChi Key HRYLQFBHBWLLLL-AHNJNIBGSA-N Canonical SMILES CC1=CCCC(=CC2C(CC1)C(=C)C(=O)O2)C Isomeric SMILES C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C WGK Germany 3 RTECS LY4270000 PubChem CID 5281437 Molecular Weight 232.32 Reaxy-Rn 14451
Chemical and Physical Properties Solubility Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C)., Specific Rotation[α] 118° (C=0.2,CHCl3) Melt Point(°C) 106°C(lit.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H317: May cause an allergic skin reaction
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS LY4270000 Reaxy-Rn 14451
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