Agonist of CB 1 receptor;Agonist of CB 2 receptor;Agonist of GPR55;Antagonist of GPR55
Product Description
CP-55940 is a cannabimimetic small molecule and a potent cannabinoid receptor agonist, demonstrating similar binding activity at both receptor types (CB1 K|i|=0.58 nM, CB2 K|i|=0.69 nM). CP-55940 represents a useful non-selective agonist entry into the growing library of synthetic cannabimimetics, compounds which are being actively explored for efficacy in perturbing Alzheimer′s disease and other neurodegenerative states.
1.Kapur A, Zhao P, Sharir H, Bai Y, Caron MG, Barak LS, Abood ME. (2009) Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.. J Biol Chem, 284 (43):(29817-27). [PMID:19723626]
2.Petitet F, Donlan M, Michel A. (2006) GPR55 as a new cannabinoid receptor: still a long way to prove it.. Chem Biol Drug Des, 67 (3):(252-3). [PMID:16611220]
3.Blaazer AR, Lange JH, van der Neut MA, Mulder A, den Boon FS, Werkman TR, Kruse CG, Wadman WJ. (2011) Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity.. Eur J Med Chem, 46 (10):(5086-98). [PMID:21885167]
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