Skip to the beginning of the images gallery

CR4056 , CAS No.1004997-71-0, Inhibitor of Monoamine oxidase A

Moligand™
≥98%

CAS#: 1004997-71-0
Formula: C₁₇H₁₂N₄
Molecular Weight: 272.3
PubChem CID: 24898732

Item Number

C609595

Grouped product items
SKU	Size	Availability	Price
C609595-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$185.90
C609595-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$415.90
C609595-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$613.90
C609595-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$937.90
C609595-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$979.90

View related series

MAO Monoamine oxidase A Inhibitor

Basic Description

Synonyms	6-imidazol-1-yl-2-phenylquinazoline \| cr4056 \| CR-4056 \| 2-Phenyl-6-(1H-imidazol-1-yl)quinazoline \| 6-(1H-imidazol-1-yl)-2-phenylquinazoline \| Quinazoline
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Monoamine oxidase A
Product Description	CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) is a selective inhibitor of MAO-A with IC50 of 202.7 nM and a ligand of I2-imidazoline receptor with IC50 of 596 nM.

Associated Targets

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B 0 Activities

Discover Target: MAOB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 1 Activities

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-imidazol-1-yl-2-phenylquinazoline
INCHI	InChI=1S/C17H12N4/c1-2-4-13(5-3-1)17-19-11-14-10-15(6-7-16(14)20-17)21-9-8-18-12-21/h1-12H
InChi Key	CSZGXYBGYFNSCO-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=NC=C3C=C(C=CC3=N2)N4C=CN=C4
Isomeric SMILES	C1=CC=C(C=C1)C2=NC=C3C=C(C=CC3=N2)N4C=CN=C4
Alternate CAS	1004997-71-0
PubChem CID	24898732
MeSH Entry Terms	CR4056
Molecular Weight	272.3

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
G2418177	Certificate of Analysis	Apr 17, 2024	C609595
G2418178	Certificate of Analysis	Apr 17, 2024	C609595
G2418179	Certificate of Analysis	Apr 17, 2024	C609595
G2418181	Certificate of Analysis	Apr 17, 2024	C609595
G2418182	Certificate of Analysis	Apr 17, 2024	C609595
G2418183	Certificate of Analysis	Apr 17, 2024	C609595
G2418184	Certificate of Analysis	Apr 17, 2024	C609595
G2418185	Certificate of Analysis	Apr 17, 2024	C609595
G2418186	Certificate of Analysis	Apr 17, 2024	C609595
G2418187	Certificate of Analysis	Apr 17, 2024	C609595

References

1. Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, Giordani A, Lanza M, Caselli G. (2011) Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain.. J Pain Res, 4 (3): (111-25). [PMID:21647215]
2. Thorn DA, Qiu Y, Jia S, Zhang Y, Li JX. (2016) Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats.. Behav Pharmacol, 27 (4): (377-83). [PMID:26599907]
3. Li JX. (2017) Imidazoline I₂ receptors: An update.. Pharmacol Ther, 178 (3): (48-56). [PMID:28322973]
4. Siemian JN, Wang K, Zhang Y, Li JX. (2018) Mechanisms of imidazoline I₂ receptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission.. Br J Pharmacol, 175 (9): (1519-1534). [PMID:29451703]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.